Hermansen Maja, Nygaard Marianne, Tan Qihua, Jeune Bernard, Semkovska Maria, Christensen Kaare, Thinggaard Mikael, Mengel-From Jonas
The Danish Twin Registry and Danish Aging Research Center, Department of Public Health, University of Southern Denmark, Odense, Denmark.
The Danish Twin Registry and Danish Aging Research Center, Department of Public Health, University of Southern Denmark, Odense, Denmark; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Arch Gerontol Geriatr. 2024 Jul;122:105398. doi: 10.1016/j.archger.2024.105398. Epub 2024 Mar 4.
Preserving cognitive function with age or super-aging greatly contributes to successful aging. Super-aging nonagenarians born in Denmark in either year 1905 or 1915 were classified as Cognitively High-Performing Oldest Old individuals with a five item cognitive composite score, equivalent to or better than mean middle-aged subjects. Cognitively high-performers were more physically active and had a better physical performance on e.g., Activity of Daily Living (p-value < 0.01), gait speed (p-value < 0.01) and grip strength (p-value < 0.05) compared with age-matched peers. Cognitive high-performing was also linked to lower depression symptomatology. When comparing super-agers with semi super-agers classified by Mini Mental State Examination > 27, super-agers were still more physically active and had a better physical performance (p-value < 0.05). Results suggests that physical activity is a lifestyle factor strongly associated with both semi and full cognitive super-aging.
随着年龄增长保持认知功能或实现超级老龄化对成功老龄化有很大贡献。1905年或1915年出生于丹麦的超级老龄化非agenarians被归类为认知功能高的最年长者，其五项认知综合得分等同于或优于中年受试者的平均水平。与年龄匹配的同龄人相比，认知功能高的人身体更活跃，在例如日常生活活动（p值<0.01）、步速（p值<0.01）和握力（p值<0.05）方面有更好的身体表现。认知功能高还与较低的抑郁症状相关。当将超级老龄化者与通过简易精神状态检查表>27分类的半超级老龄化者进行比较时，超级老龄化者仍然身体更活跃且身体表现更好（p值<0.05）。结果表明，身体活动是与半认知和完全认知超级老龄化都密切相关的生活方式因素。
