St. Andrews Biological Station, Fisheries and Oceans Canada, St. Andrews, NB E5B 0E4, Canada.
National Contaminants Advisory Group, Fisheries and Oceans Canada, Ottawa, ON K2P 2J8, Canada.
Mar Pollut Bull. 2024 Apr;201:116213. doi: 10.1016/j.marpolbul.2024.116213. Epub 2024 Mar 8.
We have updated and reviewed toxicity data for Emamectin benzoate (EMB) and Ivermectin (IVER), two in-feed drugs used to treat sea lice in farmed Atlantic salmon, and inferred new Environmental Quality Standards (EQS) using a deterministic approach or Species Sensitivity Distributions (SSDs) based on available data. We used a SSD model averaging approach and inferred a water acute EQS value of 24.9 ng/L (SSD) for EMB, while previously established chronic water EQS of 0.17 ng/L and sediment benthic EQS of 131 ng/kg dry weight remained unchanged. For IVER, both a water acute EQS of 8.04 ng/L and a chronic water EQS of 3.98 ng/L were inferred using SSDs as well as a benthic EQS of 290 ng/kg dry weight using a deterministic approach. In light of the lack of solubility and tendency of both avermectins to sorb to material benthic EQSs remain the most relevant value to consider for regulators.
我们更新并审查了苯甲醯胺（EMB）和依维菌素（IVER）的毒性数据，这两种都是用于治疗养殖大西洋鲑鱼海虱的饲料内用药，并使用确定性方法或基于现有数据的物种敏感性分布（SSD）推断了新的环境质量标准（EQS）。我们使用 SSD 模型平均方法推断 EMB 的水急性 EQS 值为 24.9ng/L（SSD），而先前建立的慢性水 EQS 值 0.17ng/L 和底栖沉积物 EQS 值 131ng/kg 干重保持不变。对于IVER，我们使用 SSD 推断了水急性 EQS 值为 8.04ng/L 和慢性水 EQS 值为 3.98ng/L，以及使用确定性方法推断了底栖 EQS 值为 290ng/kg 干重。鉴于这两种阿维菌素的溶解度低和易被物质吸附的特性，底栖 EQS 仍然是监管机构最需要考虑的相关值。
