Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Int J Hyg Environ Health. 2024 May;258:114336. doi: 10.1016/j.ijheh.2024.114336. Epub 2024 Mar 8.
Previous studies have suggested that prenatal exposure to organophosphate flame retardants (OPFRs) may have adverse effect on early neurodevelopment, but limited data are available in China, and the overall effects of OPFRs mixture are still unclear.
This study aimed to investigate the association between prenatal exposure to OPFR metabolites mixture and the neurodevelopment of 1-year-old infants.
A total of 270 mother-infant pairs were recruited from the Laizhou Wan (Bay) Birth Cohort in China. Ten OPFR metabolites were measured in maternal urine. Neurodevelopment of 1-year-old infants was assessed using the Gesell Developmental Schedules (GDS) and presented by the developmental quotient (DQ) score. Multivariate linear regression and weighted quantile sum (WQS) regression models were conducted to estimate the association of prenatal exposure to seven individual OPFR metabolites and their mixture with infant neurodevelopment.
The positive rates of seven OPFR metabolites in the urine of pregnant women were greater than 70% with the median concentration ranged within 0.13-3.53 μg/g creatinine. The multivariate linear regression model showed significant negative associations between bis (1-chloro-2-propyl) phosphate (BCIPP), din-butyl phosphate (DnBP), and total OPFR metabolites exposure and neurodevelopment in all infants. Results from the WQS model consistently revealed that the OPFR metabolites mixture was inversely associated with infant neurodevelopment. Each quartile increased in the seven OPFR metabolites mixture was associated with a 1.59 decrease (95% CI: 2.96, -0.21) in gross motor DQ scores, a 1.41 decrease (95% CI: 2.38, -0.43) in adaptive DQ scores, and a 1.08 decrease (95% CI: 2.15, -0.02) in social DQ scores, among which BCIPP, bis (1, 3-dichloro-2-propyl) phosphate (BDCIPP) and DnBP were the main contributors.
Prenatal exposure to a mixture of OPFRs was negatively associated with early infant neurodevelopment, particularly in gross motor, adaptive, and social domains.
先前的研究表明，产前接触有机磷阻燃剂（OPFRs）可能对早期神经发育有不良影响，但中国的相关数据有限，OPFRs 混合物的整体影响仍不清楚。
本研究旨在探讨产前接触 OPFRs 代谢物混合物与 1 岁婴儿神经发育的关系。
本研究共纳入了 270 对来自中国莱州湾（Bay）出生队列的母婴。检测了 10 种 OPFR 代谢物在孕妇尿液中的浓度。采用 Gesell 发育量表（GDS）评估 1 岁婴儿的神经发育情况，并用发育商（DQ）评分表示。采用多元线性回归和加权总量得分（WQS）回归模型来评估 7 种个体 OPFR 代谢物及其混合物与婴儿神经发育的关系。
孕妇尿液中 7 种 OPFR 代谢物的阳性率均大于 70%，中位数浓度范围在 0.13-3.53μg/g 肌酐之间。多元线性回归模型显示，双（1-氯-2-丙基）磷酸酯（BCIPP）、二正丁基磷酸酯（DnBP）和总 OPFR 代谢物暴露与所有婴儿的神经发育呈显著负相关。WQS 模型的结果一致表明，OPFR 代谢物混合物与婴儿的神经发育呈负相关。7 种 OPFR 代谢物混合物每增加一个四分位间距，粗大运动发育商（DQ）评分降低 1.59（95%置信区间：2.96，-0.21），适应行为 DQ 评分降低 1.41（95%置信区间：2.38，-0.43），社会交往 DQ 评分降低 1.08（95%置信区间：2.15，-0.02），其中 BCIPP、双（1,3-二氯-2-丙基）磷酸酯（BDCIPP）和 DnBP 是主要贡献者。
产前接触 OPFRs 混合物与婴儿早期神经发育不良有关，尤其是在粗大运动、适应行为和社会交往方面。
