Yao Xiaohong, Feng Min, Wang Wei
Department of Pathology, West China Second University Hospital, Sichuan University, Sichuan, Chengdu, People's Republic of China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, People's Republic of China.
Cancer Manag Res. 2024 Mar 4;16:117-125. doi: 10.2147/CMAR.S445055. eCollection 2024.
Endometrial cancer shows high histological and molecular heterogeneity. The mutation is a significant molecular alteration in endometrial cancer, leading to the identification of a specific subtype known as -mutated endometrial cancer. This subtype exhibits a high tumor mutation burden, abundant lymphocyte infiltration, and a favorable prognosis, making it a promising candidate for immune checkpoint inhibitor therapy. This paper presents a comprehensive review of the clinical and pathological characteristics, outcomes, treatment advancements, pathogenic gene detection, and alternative testing methods for -mutated endometrial cancer.
子宫内膜癌具有高度的组织学和分子异质性。该突变是子宫内膜癌的一种重要分子改变，导致一种特定亚型的识别，即 - 突变型子宫内膜癌。这种亚型表现出高肿瘤突变负荷、丰富的淋巴细胞浸润以及良好的预后，使其成为免疫检查点抑制剂治疗的一个有前景的候选对象。本文对 - 突变型子宫内膜癌的临床和病理特征、治疗结果、治疗进展、致病基因检测以及替代检测方法进行了全面综述。
