Paulino Yvette C, Camacho Frank, Paulino Tristan Vc, Lee Delores J, Natividad Lisa Linda, Matisoo-Smith Elizabeth, Merriman Tony R, Gosling Anna
University of Guam.
University of Otago.
Res Sq. 2024 Feb 22:rs.3.rs-3955100. doi: 10.21203/rs.3.rs-3955100/v1.
Gout, the most common inflammatory arthritis disease, and hyperuricaemia onset are influenced by environmental and genetic factors. We sought to investigate these factors in an Indigenous community in Guam.
In this cross-sectional study, the University of Guam led the qualitative inquiry with the native community, training (pre-screening of participants, data collection methods, and biospecimen handling), study implementation (outreach and recruitment, data collection, and DNA extraction and quantification), and qualitative and epidemiologic data analyses. Recruitment targets were based on demographic representation in current census data. The University of Otago collaborated on ethics guidance, working with Indigenous communities, and led the genetic sequencing and genetic data analysis. Participants were recruited in Guam from Fall 2019 to Spring 2022.
Of the 359 participants, most self-identified as Native CHamorus (61.6%) followed by Other Micronesians (22.0%), and Filipinos (15.6%). The prevalence of metabolic conditions from highest to lowest were obesity (55.6%), hyperuricaemia (36.0%), hypertension (27.8%), gout (23.0%), diabetes (14.9%), cardiovascular disease (8.4%), kidney disease (7.3%), and liver disease (3.4%). Compared to Filipinos and Other Micronesians, significantly more CHamorus had hyperuricaemia (42.1% versus 26.8% in Filipinos and 25.3% in Other Micronesians), gout (28.5% versus 21.4% and 8.9%), diabetes (19.5% versus 8.9% and 6.3%), and hypertension (33.9% versus 19.6% and 16.5%).
We estimated the prevalence of metabolic conditions, especially gout and hyperuricaemia, and found statistical differences among major ethnic groups in Guam, all while obtaining the Indigenous community's feedback on the genetic study and building gout research capacity. The results of ongoing genetic sequencing will be used to understand molecular causes of gout in Guam.
痛风是最常见的炎性关节炎疾病，高尿酸血症的发病受环境和遗传因素影响。我们试图在关岛的一个原住民社区调查这些因素。
在这项横断面研究中，关岛大学主导了与当地社区的定性调查、培训（参与者预筛查、数据收集方法和生物样本处理）、研究实施（外展与招募、数据收集以及DNA提取和定量）以及定性和流行病学数据分析。招募目标基于当前人口普查数据中的人口统计学代表性。奥塔哥大学在伦理指导、与原住民社区合作方面提供协作，并主导基因测序和基因数据分析。2019年秋季至2022年春季在关岛招募参与者。
在359名参与者中，大多数人自我认定为查莫罗原住民（61.6%），其次是其他密克罗尼西亚人（22.0%）和菲律宾人（15.6%）。代谢性疾病的患病率从高到低依次为肥胖（55.6%）、高尿酸血症（36.0%）、高血压（27.8%）、痛风（23.0%）、糖尿病（14.9%）、心血管疾病（8.4%）、肾脏疾病（7.3%）和肝脏疾病（3.4%）。与菲律宾人和其他密克罗尼西亚人相比，查莫罗人患高尿酸血症（42.1%，而菲律宾人为26.8%，其他密克罗尼西亚人为25.3%）、痛风（28.5%，而菲律宾人为21.4%，其他密克罗尼西亚人为8.9%）、糖尿病（19.5%，而菲律宾人为8.9%，其他密克罗尼西亚人为6.3%）和高血压（33.9%，而菲律宾人为19.6%，其他密克罗尼西亚人为16.5%）的比例明显更高。
我们估计了代谢性疾病的患病率，尤其是痛风和高尿酸血症，并发现关岛主要种族群体之间存在统计学差异，同时获得了原住民社区对基因研究的反馈并建立了痛风研究能力。正在进行的基因测序结果将用于了解关岛痛风的分子病因。
