Chen Tian, Gao Chengjiang
Key Laboratory of Infection and Immunity of Shandong Province & Key Laboratory for Experimental Teratology of Ministry of Education, Shandong University, Jinan, 250012, Shandong, China.
Department of Pathogenic Biology, School of Biomedical Sciences, Shandong University, Jinan, 250012, Shandong, China.
Cell Insight. 2024 Feb 10;3(3):100154. doi: 10.1016/j.cellin.2024.100154. eCollection 2024 Jun.
species are significant causes of mucosal and systemic infections in immune compromised populations, including HIV-infected individuals and cancer patients. Drug resistance and toxicity have limited the use of anti-fungal drugs. A good comprehension of the nature of the immune responses to the pathogenic fungi will aid in the developing of new approaches to the treatment of fungal diseases. In recent years, extensive research has been done to understand the host defending systems to fungal infections. In this review, we described how pattern recognition receptors senses the cognate fungal ligands and the cellular and molecular mechanisms of anti-fungal innate immune responses. Furthermore, particular focus is placed on how anti-fungal signal transduction cascades are being activated for host defense and being modulated to better treat the infections in terms of immunotherapy. Understanding the role that these pathways have in mediating host anti-fungal immunity will be crucial for future therapeutic development.
真菌物种是免疫功能低下人群（包括艾滋病毒感染者和癌症患者）黏膜和全身感染的重要原因。耐药性和毒性限制了抗真菌药物的使用。深入了解对致病真菌免疫反应的本质将有助于开发治疗真菌疾病的新方法。近年来，为了解宿主对真菌感染的防御系统进行了广泛研究。在本综述中，我们描述了模式识别受体如何感知同源真菌配体以及抗真菌固有免疫反应的细胞和分子机制。此外，特别关注抗真菌信号转导级联如何被激活以进行宿主防御，以及如何在免疫治疗方面进行调节以更好地治疗感染。了解这些途径在介导宿主抗真菌免疫中的作用对于未来的治疗发展至关重要。
