Riess H, Binsack T, Hiller E
Blut. 1985 May;50(5):303-6. doi: 10.1007/BF00319757.
Protein C, a potent anticoagulant, has been detected in large amounts in some prothrombin complex concentrates (PCC). We extended these findings to eight PCC commercially available in West Germany detecting 0.82 to 1.92 plasma equivalent units of protein C antigen (PC:Ag) per unit factor IX. Infusion of PCC in four patients on stable oral anticoagulation resulted in a recovery of 58.6 +/- 10.9%. Estimated from the decrease in plasma levels of PC:Ag half life was 7.9 +/- 0.6 h.
蛋白C是一种强效抗凝剂，在一些凝血酶原复合物浓缩剂（PCC）中已检测到大量存在。我们将这些研究结果扩展至在西德市售的8种PCC，发现每单位因子IX含有0.82至1.92血浆当量单位的蛋白C抗原（PC:Ag）。对4例接受稳定口服抗凝治疗的患者输注PCC后，回收率为58.6±10.9%。根据PC:Ag血浆水平的下降情况估算，半衰期为7.9±0.6小时。
