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白细胞介素-40作为诊断炎症性疾病生物标志物作用的综合综述

A Comprehensive Review on the Role of Interleukin-40 as a Biomarker for Diagnosing Inflammatory Diseases.

作者信息

Dabbagh-Gorjani Feryal

机构信息

Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

Autoimmune Dis. 2024 Mar 1;2024:3968767. doi: 10.1155/2024/3968767. eCollection 2024.

DOI:10.1155/2024/3968767
PMID:38464677
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10923619/
Abstract

Interleukins are a group of proteins that have a wide range of complex functions and are believed to be involved in several diseases and conditions. In particular, interleukin-40 (IL-40) is a recently identified cytokine associated with B cells that was first introduced by Catalan et al. in 2017. This cytokine has several roles in the body, including functioning in the formation of B cells in the bone marrow, IgA production, and expression in the intestinal microbiome. Moreover, IL-40 appears to be involved in numerous autoimmune and inflammatory conditions, such as rheumatoid arthritis, systemic lupus erythematosus, primary Sjogren's syndrome, ankylosing spondylitis, type 2 diabetes, Graves' disease, and hepatic cell carcinoma. Our understanding of this molecule is quite restricted due to its novelty. However, because of its inflammatory characteristics, there is a high probability that it contributes to a variety of inflammatory disease complications. The aim of the present review is to highlight all available data on the importance of assessing IL-40 levels in human diseases up to now, which could be used as a diagnostic biomarker for the onset or progression of numerous inflammatory diseases.

摘要

白细胞介素是一类具有广泛复杂功能的蛋白质，被认为与多种疾病和病症有关。特别是，白细胞介素-40（IL-40）是一种最近发现的与B细胞相关的细胞因子，由加泰罗尼亚等人于2017年首次提出。这种细胞因子在体内具有多种作用，包括在骨髓中B细胞的形成、IgA的产生以及在肠道微生物群中的表达。此外，IL-40似乎参与了许多自身免疫和炎症性病症，如类风湿性关节炎、系统性红斑狼疮、原发性干燥综合征、强直性脊柱炎、2型糖尿病、格雷夫斯病和肝细胞癌。由于其新颖性,我们对这种分子的了解相当有限。然而，由于其炎症特性，它很有可能导致各种炎症性疾病并发症。本综述的目的是强调目前所有关于评估人类疾病中IL-40水平重要性的可用数据，这些数据可作为多种炎症性疾病发病或进展的诊断生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792f/10923619/912426f372f8/AD2024-3968767.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792f/10923619/c730bccca575/AD2024-3968767.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792f/10923619/662e4758c7ca/AD2024-3968767.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792f/10923619/9c2926623f15/AD2024-3968767.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792f/10923619/9cc1ddee8184/AD2024-3968767.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792f/10923619/912426f372f8/AD2024-3968767.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792f/10923619/c730bccca575/AD2024-3968767.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792f/10923619/662e4758c7ca/AD2024-3968767.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792f/10923619/9c2926623f15/AD2024-3968767.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792f/10923619/9cc1ddee8184/AD2024-3968767.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792f/10923619/912426f372f8/AD2024-3968767.005.jpg

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RMD Open. 2023 May;9(2). doi: 10.1136/rmdopen-2022-002738.
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