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血管生成素-1、血管生成素-2和酪氨酸激酶2是过敏性紫癜和儿童期系统性红斑狼疮的诊断生物标志物。

Ang-1, Ang-2, and Tie2 are diagnostic biomarkers for Henoch-Schönlein purpura and pediatric-onset systemic lupus erythematous.

作者信息

Jia Lishan, Li Xiaozhong, Shen Jiayun, Teng Yan, Zhang Baoqin, Zhang Min, Gu Yueqin, Xu Hong

机构信息

Department of Pediatrics, Taicang Affiliated Hospital of Soochow University, The First People's Hospital of Taicang, No. 58 Changsheng South Road, Taicang City, Jiangsu Province, 215400, China.

Department of Nephrology and Immunology, Children's Hospital of Soochow University, No. 303 Jingde Road, Gusu District, Suzhou City, Jiangsu Province, 215003, China.

出版信息

Open Life Sci. 2024 Feb 8;19(1):20220812. doi: 10.1515/biol-2022-0812. eCollection 2024.

DOI:10.1515/biol-2022-0812
PMID:38465338
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10921503/
Abstract

Henoch-Schönlein purpura (HSP) and pediatric-onset systemic lupus erythematosus (pSLE) are closely associated with vasculitis and vascular diseases. This study aimed to investigate the clinical diagnostic values of Ang-1, Ang-2, and Tie2 for HSP and pSLE. We surveyed 82 HSP patients, 34 pSLE patients, and 10 healthy children. The expression levels of Ang-1, Ang-2, and Tie2 in the serum and urine were assessed using enzyme-linked immunosorbent assay. The diagnostic values of Ang-1, Ang-2, and Tie2 for HSP and pSLE were evaluated using receiver operating characteristic curve analysis. The results revealed that the serum and urine expression levels of Ang-2 and Tie2 were significantly elevated in HSP and pSLE patients, whereas the Ang-1/Ang-2 values were reduced. Additionally, Ang-1 was highly expressed in the serum and urine of HSP patients and in the serum of pSLE patients. Ang-1, Ang-2, and Tie2 showed differential expression in various types of HSP and pSLE compared with their expression in healthy controls. In summary, Ang-1, Ang-2, and Tie2 can serve as biomarkers for HSP and pSLE. Moreover, Ang-1/Ang-2 values are reduced in HSP and pSLE patients. Ang-1, Ang-2, and Tie2 can be used as biomarkers for HSP and pSLE.

摘要

过敏性紫癜（HSP）和儿童期起病的系统性红斑狼疮（pSLE）与血管炎和血管疾病密切相关。本研究旨在探讨血管生成素-1（Ang-1）、血管生成素-2（Ang-2）和酪氨酸激酶2（Tie2）对HSP和pSLE的临床诊断价值。我们调查了82例HSP患者、34例pSLE患者和10名健康儿童。采用酶联免疫吸附测定法评估血清和尿液中Ang-1、Ang-2和Tie2的表达水平。采用受试者工作特征曲线分析评估Ang-1、Ang-2和Tie2对HSP和pSLE的诊断价值。结果显示，HSP和pSLE患者血清和尿液中Ang-2和Tie2的表达水平显著升高，而Ang-1/Ang-2值降低。此外，Ang-1在HSP患者的血清和尿液以及pSLE患者的血清中高表达。与健康对照相比，Ang-1、Ang-2和Tie2在不同类型的HSP和pSLE中表现出差异表达。总之，Ang-1、Ang-2和Tie2可作为HSP和pSLE的生物标志物。此外，HSP和pSLE患者的Ang-1/Ang-2值降低。Ang-1、Ang-2和Tie2可作为HSP和pSLE的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b1/10921503/d5ece8fafe30/j_biol-2022-0812-fig005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b1/10921503/fce086abb75b/j_biol-2022-0812-ga001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b1/10921503/5db06158c952/j_biol-2022-0812-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b1/10921503/57c7cd5905d1/j_biol-2022-0812-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b1/10921503/07e191995e43/j_biol-2022-0812-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b1/10921503/7b2468277899/j_biol-2022-0812-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b1/10921503/d5ece8fafe30/j_biol-2022-0812-fig005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b1/10921503/fce086abb75b/j_biol-2022-0812-ga001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b1/10921503/5db06158c952/j_biol-2022-0812-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b1/10921503/57c7cd5905d1/j_biol-2022-0812-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b1/10921503/07e191995e43/j_biol-2022-0812-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b1/10921503/7b2468277899/j_biol-2022-0812-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b1/10921503/d5ece8fafe30/j_biol-2022-0812-fig005.jpg

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