The Third Clinical Medical College, Fujian Medical University, Fuzhou.
Department of Neurosurgery, the First Hospital of Putian, Putain.
Blood Press Monit. 2024 Aug 1;29(4):173-179. doi: 10.1097/MBP.0000000000000698. Epub 2024 Mar 11.
The purpose of our study was to analyze the association of blood pressure and blood pressure progression with heart disease and stroke among Chinese population.
We included a total of 10 122 adults aged 45 years and above free of heart disease or stroke at baseline from the China Health and Retirement Longitudinal Study cohort. We used Cox proportional hazards models to analyze the relationship between cardiovascular risk and prehypertension in subjects with or without progression to hypertension.
During a mean follow-up of 6.5 years, 1972 subjects were either diagnosed with heart disease or had a stroke (composite outcome). Compared with individuals with normotension at baseline, the fully adjusted hazard ratio (HR) [95% confidence interval (CI)] was 1.25 (1.10-1.42) and 1.52 (1.34-1.74) for composite outcome in individuals with prehypertension and hypertension at baseline, respectively. The subjects who progressed to hypertension had higher risk of cardiovascular outcomes than those who remained at normal blood pressure or prehypertension in a fully adjusted model. The subjects who progressed from prehypertension to hypertension had 1.72 times higher risk [HR (95% CI): 1.72 (1.37-2.16)] of cardiovascular outcomes than those who remained at normal blood pressure or prehypertension in a fully adjusted model.
The cardiovascular risk of subjects with prehypertension is higher than that of subjects with normal blood pressure. After a diagnosis of hypertension, subjects who progressed from normal blood pressure to hypertension had an increased risk of heart disease and stroke.
本研究旨在分析中国人群的血压和血压进展与心脏病和中风之间的关联。
我们纳入了来自中国健康与退休纵向研究队列的共 10122 名年龄在 45 岁及以上、基线时无心脏病或中风的成年人。我们使用 Cox 比例风险模型分析了伴有或不伴有高血压进展的受试者中，心血管风险与高血压前期之间的关系。
在平均 6.5 年的随访期间，共有 1972 名受试者被诊断患有心脏病或发生中风（复合结局）。与基线时血压正常的个体相比，基线时患有高血压前期和高血压的个体的全调整风险比（HR）[95%置信区间（CI）]分别为 1.25（1.10-1.42）和 1.52（1.34-1.74）。在完全调整模型中，进展为高血压的受试者发生心血管结局的风险高于仍处于正常血压或高血压前期的受试者。在完全调整模型中，从高血压前期进展为高血压的受试者发生心血管结局的风险是仍处于正常血压或高血压前期的受试者的 1.72 倍[HR（95% CI）：1.72（1.37-2.16）]。
高血压前期患者的心血管风险高于血压正常患者。在诊断为高血压后，从正常血压进展为高血压的受试者发生心脏病和中风的风险增加。
