四乙铵盐作为固态、易于处理的乙烯前体及其在 Mizoroki-Heck 偶联反应中的应用
Tetraethylammonium Salts as Solid, Easy to Handle Ethylene Precursors and Their Application in Mizoroki-Heck Coupling.
作者信息
Papaplioura Eleni, Mercier Maëva, Muratore Michael E, Biberger Tobias, Jerhaoui Soufyan, Schnürch Michael
机构信息
Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/163, 1060 Wien, Austria.
Discovery Science, Discovery Chemistry BE, Janssen Pharmaceutica N.V., Turnhoutseweg 30, 2340 Beerse, Belgium.
出版信息
J Org Chem. 2024 Apr 5;89(7):5126-5133. doi: 10.1021/acs.joc.3c02867. Epub 2024 Mar 11.
In this study, we introduce a convenient Heck vinylation protocol that eliminates the requirement for ethylene gas as a coupling partner. In contrast to traditional methodologies, quaternary ammonium salts can serve as solid olefin precursors under ambient atmosphere conditions. The practicality of this method, distinguished by its convenience and safety in a one-pot reaction, renders it appealing for applications in research and discovery context.
在本研究中，我们引入了一种便捷的Heck乙烯基化方案，该方案无需使用乙烯气体作为偶联伙伴。与传统方法不同，季铵盐在环境大气条件下可作为固体烯烃前体。该方法的实用性体现在其在一锅反应中的便利性和安全性，使其在研究与发现领域具有吸引力。
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