Cefalo Chiara Maria Assunta, Riccio Alessia, Fiorentino Teresa Vanessa, Succurro Elena, Mannino Gaia Chiara, Perticone Maria, Sciacqua Angela, Andreozzi Francesco, Sesti Giorgio
Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Department of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Catanzaro, Italy.
Obesity (Silver Spring). 2024 May;32(5):888-899. doi: 10.1002/oby.24006. Epub 2024 Mar 11.
Reduced myocardial mechano-energetic efficiency (MEE) was associated with BMI. Subgroups of individuals with increased BMI but favorable cardiovascular risk profile were identified as individuals with "metabolically healthy overweight" (MHOW) and "metabolically healthy obesity" (MHO), respectively. We aim to investigate whether those with MHOW/MHO, defined as those having none of the components of metabolic syndrome, exhibit impaired MEE compared with their unhealthy counterparts.
Myocardial MEE per gram of left ventricular mass (MEEi) was assessed by echocardiography in 2190 nondiabetic individuals participating in the CATAnzaro MEtabolic RIsk factors (CATAMERI) study who were divided, according to BMI and metabolic status, into groups of individuals with metabolically healthy normal weight (MHNW), metabolically unhealthy normal weight (MUNW), MHOW, metabolically unhealthy overweight (MUOW), MHO, and metabolically unhealthy obesity (MUO).
After adjusting for age and sex, no differences in myocardial MEEi were observed among individuals with MHNW, MHOW, and MHO (p = 0.56). Myocardial MEEi was comparable among individuals with MUNW, MUOW, and MUO (p = 0.21). Individuals with MHNW, MHOW, and MHO displayed significantly higher myocardial MEEi compared with their unhealthy counterparts.
Increased BMI is not an obligate determinant for reduced myocardial MEEi. Other known components of metabolic syndrome rather than increased BMI contributed to reduced myocardial MEEi.
心肌机械能量效率（MEE）降低与体重指数（BMI）相关。体重指数增加但心血管风险状况良好的个体亚组分别被确定为“代谢健康超重”（MHOW）和“代谢健康肥胖”（MHO）个体。我们旨在研究那些被定义为没有代谢综合征任何成分的MHOW/MHO个体与不健康的对应个体相比，是否表现出MEE受损。
在参与卡坦扎罗代谢风险因素（CATAMERI）研究的2190名非糖尿病个体中，通过超声心动图评估每克左心室质量的心肌MEE（MEEi）。这些个体根据BMI和代谢状态被分为代谢健康正常体重（MHNW）、代谢不健康正常体重（MUNW）、MHOW、代谢不健康超重（MUOW）、MHO和代谢不健康肥胖（MUO）组。
在调整年龄和性别后，MHNW、MHOW和MHO个体之间未观察到心肌MEEi的差异（p = 0.56）。MUNW、MUOW和MUO个体之间的心肌MEEi相当（p = 0.21）。与不健康的对应个体相比，MHNW、MHOW和MHO个体的心肌MEEi显著更高。
BMI增加并非心肌MEEi降低的必然决定因素。代谢综合征的其他已知成分而非BMI增加导致心肌MEEi降低。
