Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Adv Exp Med Biol. 2024;1444:145-161. doi: 10.1007/978-981-99-9781-7_10.
Inflammation is a complex process that protects our body from various insults such as infection, injury, and stress. Proper inflammation is beneficial to eliminate the insults and maintain organ homeostasis, however, it can become detrimental if uncontrolled. To tightly regulate inflammation, post-transcriptional mechanisms governing RNA metabolism play a crucial role in monitoring the expression of immune-related genes, such as tumor necrosis factor (TNF) and interleukin-6 (IL-6). These mechanisms involve the coordinated action of various RNA-binding proteins (RBPs), including the Regnase family, Roquin, and RNA methyltransferases, which are responsible for mRNA decay and/or translation regulation. The collaborative efforts of these RBPs are essential in preventing aberrant immune response activation and consequently safeguarding against inflammatory and autoimmune diseases. This review provides an overview of recent advancements in our understanding of post-transcriptional regulation within the immune system and explores the specific roles of individual RBPs in RNA metabolism and regulation.
炎症是一个复杂的过程，它可以保护我们的身体免受各种伤害，如感染、损伤和压力。适当的炎症对消除这些伤害和维持器官内环境稳定是有益的，但是如果炎症失控，它就会变得有害。为了严格控制炎症，调控 RNA 代谢的转录后机制在监测免疫相关基因（如肿瘤坏死因子 (TNF) 和白细胞介素-6 (IL-6)）的表达方面起着至关重要的作用。这些机制涉及各种 RNA 结合蛋白 (RBP) 的协调作用，包括 Regnase 家族、Roquin 和 RNA 甲基转移酶，它们负责 mRNA 的降解和/或翻译调控。这些 RBP 的协同作用对于防止异常免疫反应的激活以及炎症和自身免疫性疾病的发生至关重要。这篇综述概述了我们对免疫系统中转录后调控的最新理解，并探讨了个别 RBP 在 RNA 代谢和调控中的特定作用。
