前额叶皮质直流电刺激对进行性核上性麻痹无效：一项随机试验。
Direct Current Stimulation of Prefrontal Cortex Is Not Effective in Progressive Supranuclear Palsy: A Randomized Trial.
机构信息
Center for Neurodegenerative diseases (CEMAND), Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Fisciano, Italy.
Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy.
出版信息
Mov Disord. 2024 Jun;39(6):1043-1048. doi: 10.1002/mds.29774. Epub 2024 Mar 12.
BACKGROUND
Progressive supranuclear palsy (PSP) is a rare 4R-tauopathy. Transcranial direct current stimulation (tDCS) may improve specific symptoms.
OBJECTIVES
This randomized, double-blinded, sham-controlled trial aimed at verifying the short-, mid-, and long-term effect of multiple sessions of anodal tDCS over the left dorsolateral prefrontal cortex (DLPFC) cortex in PSP.
METHODS
Twenty-five patients were randomly assigned to active or sham stimulation (2 mA for 20 minute) for 5 days/week for 2 weeks. Participants underwent assessments at baseline, after the 2-week stimulation protocol, then after 45 days and 3 months from baseline. Primary outcomes were verbal and semantic fluency. The efficacy was verified with analysis of covariance.
RESULTS
We failed to detect a significant effect of active stimulation on primary outcomes. Stimulation was associated to worsening of specific behavioral complaints.
CONCLUSIONS
A 2-week protocol of anodal left DLPFC tDCS is not effective in PSP. Specific challenges in running symptomatic clinical trials with classic design are highlighted. © 2024 International Parkinson and Movement Disorder Society.
背景
进行性核上性麻痹（PSP）是一种罕见的 4R-tau 病。经颅直流电刺激（tDCS）可能改善特定症状。
目的
本随机、双盲、假刺激对照试验旨在验证左背外侧前额叶皮质（DLPFC）经多次阳极 tDCS 对 PSP 的短期、中期和长期效果。
方法
25 名患者被随机分配到活性或假刺激（2 mA 20 分钟）组，每周 5 天，持续 2 周。参与者在基线、2 周刺激方案后、基线后 45 天和 3 个月进行评估。主要结果是语言和语义流畅性。采用协方差分析验证疗效。
结果
我们未能检测到活性刺激对主要结果的显著影响。刺激与特定行为投诉的恶化有关。
结论
为期 2 周的左 DLPFC 阳极 tDCS 方案对 PSP 无效。突出了使用经典设计进行症状性临床试验的具体挑战。
Zotero 插件