Abbas Mosab, Enani Mariam Zuhair, Alsabban Zehour, Meliti Abdelrazak, Homoud Mohammed
Department of Neuroscience, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
Department of Radiology, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
Surg Neurol Int. 2024 Feb 16;15:48. doi: 10.25259/SNI_929_2023. eCollection 2024.
Primary optic nerve and chiasmal germinomas are very rare. These lesions can commonly be mistaken for optic pathway gliomas based on imaging alone. It is radiosensitive and cured in most of the cases.
We report a rare case of a 13-year-old boy with primary bilateral optic nerves and chiasmal germinoma who underwent partial surgical resection followed by radiotherapy. Follow-up brain imaging after two months post-radiotherapy showed interval regression of the tumor. Our literature review identified that 12 reported cases of primary anterior visual pathway germinoma had been reported to regress significantly post-radiotherapy alone or with chemotherapy.
Histologic correlation is essential for appropriate treatment, alleviating symptoms, and avoiding irreversible vision loss.
原发性视神经和视交叉生殖细胞瘤非常罕见。仅根据影像学表现，这些病变通常会被误诊为视神经通路胶质瘤。它对放疗敏感，大多数病例可治愈。
我们报告了一例罕见的13岁男孩，患有原发性双侧视神经和视交叉生殖细胞瘤，接受了部分手术切除，随后进行放疗。放疗后两个月的脑部随访影像显示肿瘤有间隔性退缩。我们的文献综述发现，有12例原发性前视觉通路生殖细胞瘤的报告显示，单独放疗或联合化疗后肿瘤明显退缩。
组织学相关性对于恰当治疗、缓解症状以及避免不可逆的视力丧失至关重要。
