Ohtani Nao, Sasaki Takahiro, Yamoto Toshikazu, Fukai Junya, Nishibayashi Hiroki, Nakao Naoyuki
Department of Neurological Surgery, Wakayama Medical University, Wakayama, Japan.
Surg Neurol Int. 2024 Feb 2;15:33. doi: 10.25259/SNI_806_2023. eCollection 2024.
Gangliogliomas account for 0.4% of primary brain tumors. They mainly occur in the supratentorial compartment and typically affect only children and young adults. We present an especially rare case of cerebellar ganglioglioma in an elderly patient.
A 76-year-old Japanese woman presented with headache and nausea from 1 month previously. She had been diagnosed with a cerebellar tumor in her childhood, but the lesion was asymptomatic at that time, and there was no evidence of an increase in size, so it had been monitored without surgery. At the time of presentation, she had not been examined for approximately ten years. On admission, magnetic resonance imaging indicated a T2 hypertense cyst in the cerebellar vermis. Post-contrast T1 imaging showed an enhanced mural nodule in the cyst. Cerebral angiography showed that none of the vertebral arteries were significant feeders. The tumor was removed through posterior fossa craniotomy. The histopathological diagnosis was ganglioglioma. The patient's headache and nausea improved after surgery.
Our patient presented a very rare case of extremely slow-growing elderly ganglioglioma in the cerebellum. In patients with gangliogliomas, long-term follow-up is important because the disease may become symptomatic at an older age.
神经节胶质瘤占原发性脑肿瘤的0.4%。它们主要发生在幕上腔,通常仅影响儿童和年轻人。我们报告一例老年患者罕见的小脑神经节胶质瘤病例。
一名76岁日本女性,1个月前出现头痛和恶心症状。她童年时被诊断出患有小脑肿瘤,但当时该病灶无症状,且无增大迹象,因此未手术,一直进行观察。此次就诊时,她大约已有十年未接受检查。入院时,磁共振成像显示小脑蚓部有一个T2高信号囊肿。增强T1成像显示囊肿内有一个强化的壁结节。脑血管造影显示椎动脉均无明显供血。通过后颅窝开颅手术切除肿瘤。组织病理学诊断为神经节胶质瘤。术后患者的头痛和恶心症状有所改善。
我们的患者呈现了一例极为罕见的小脑神经节胶质瘤病例,其生长极其缓慢且发生于老年患者。对于神经节胶质瘤患者,长期随访很重要,因为该疾病可能在老年时出现症状。