Huang Kerui, Liu Ying, Perrimon Norbert
Department of Genetics, Harvard Medical School, Blavatnik Institute, Boston, MA, United States.
Harvard Medical School, Howard Hughes Medical Institute, Boston, MA, United States.
Front Insect Sci. 2022 Mar 17;2:859847. doi: 10.3389/finsc.2022.859847. eCollection 2022.
Oenocytes are large secretory cells present in the abdomen of insects known to synthesize very-long-chain fatty acids to produce hydrocarbons and pheromones that mediate courtship behavior in adult flies. In recent years, oenocytes have been implicated in the regulation of energy metabolism. These hepatocyte-like cells accumulate lipid droplets under starvation and can non-autonomously regulate tracheal waterproofing and adipocyte lipid composition. Here, we summarize evidence, mostly from , establishing that oenocytes perform liver-like functions. We also compare the functional differences in oenocytes and the fat body, another lipid storage tissue which also performs liver-like functions. Lastly, we examine signaling pathways that regulate oenocyte metabolism derived from other metabolic tissues, as well as oenocyte-derived signals that regulate energy homeostasis.
oenocytes是存在于昆虫腹部的大型分泌细胞，已知其能合成极长链脂肪酸以产生碳氢化合物和信息素，这些物质介导成年果蝇的求偶行为。近年来，oenocytes与能量代谢的调节有关。这些类似肝细胞的细胞在饥饿状态下会积累脂滴，并且能够非自主地调节气管防水性和脂肪细胞的脂质组成。在这里，我们总结了主要来自[具体来源未给出]的证据，证实oenocytes具有类似肝脏的功能。我们还比较了oenocytes与脂肪体（另一种也具有类似肝脏功能的脂质储存组织）之间的功能差异。最后，我们研究了调节oenocyte代谢的信号通路，这些信号通路源自其他代谢组织，以及oenocyte衍生的调节能量稳态的信号。
