Wu Shutong, Yang Yuchao, Zhang Meiling, Khan Asmat Ullah, Dai Jingxing, Ouyang Jun
Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, Guangdong Engineering Research Center for Translation of Medical 3D Printing Application, National Virtual & Reality Experimental Education Center for Medical Morphology (Southern Medical University), National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Xinjin Branch of Chengdu Municipal Public Security Bureau, Chengdu, China.
Front Mol Biosci. 2024 Feb 26;11:1334931. doi: 10.3389/fmolb.2024.1334931. eCollection 2024.
Serine protease inhibitors (serpins) are the most numerous and widespread multifunctional protease inhibitor superfamily and are expressed by all eukaryotes. Serpin E2 (serpin peptidase inhibitor, clade E, member 2), a member of the serine protease inhibitor superfamily is a potent endogenous thrombin inhibitor, mainly found in the extracellular matrix and platelets, and expressed in numerous organs and secreted by many cell types. The multiple functions of serpin E2 are mainly mediated through regulating urokinase-type plasminogen activator (uPA, also known as PLAU), tissue-type plasminogen activator (tPA, also known as PLAT), and matrix metalloproteinase activity, and include hemostasis, cell adhesion, and promotion of tumor metastasis. The importance serpin E2 is clear from its involvement in numerous physiological and pathological processes. In this review, we summarize the structural characteristics of the Serpin E2 gene and protein, as well as its roles physiology and disease.
丝氨酸蛋白酶抑制剂（丝氨酸蛋白酶抑制剂家族）是数量最多、分布最广的多功能蛋白酶抑制剂超家族，所有真核生物均可表达。丝氨酸蛋白酶抑制剂E2（丝氨酸蛋白酶抑制剂肽酶抑制剂，E族，成员2）是丝氨酸蛋白酶抑制剂超家族的成员，是一种有效的内源性凝血酶抑制剂，主要存在于细胞外基质和血小板中，在许多器官中表达，并由多种细胞类型分泌。丝氨酸蛋白酶抑制剂E2的多种功能主要通过调节尿激酶型纤溶酶原激活剂（uPA，也称为PLAU）、组织型纤溶酶原激活剂（tPA，也称为PLAT）和基质金属蛋白酶活性来介导，包括止血、细胞黏附以及促进肿瘤转移。丝氨酸蛋白酶抑制剂E2参与众多生理和病理过程，其重要性显而易见。在本综述中，我们总结了丝氨酸蛋白酶抑制剂E2基因和蛋白质的结构特征，以及其在生理和疾病中的作用。
