Fu Chang, Li Xiaocong, Wang Yongxin, Wang Chuangshi, Jin Hengwei, Liu Kai, Xu Hongji
Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, China.
Medical Research and Biometrics Center, National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Front Oncol. 2024 Feb 26;14:1349282. doi: 10.3389/fonc.2024.1349282. eCollection 2024.
Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare exocrine tumor of the pancreas. The aim of our study is to summarize the clinical features of SPN and to analyze the risk factors for malignant SPN.
From May 2013 to September 2022, patients who were pathologically confirmed to have SPN were retrospectively reviewed. Demographic data, clinical and pathological features, follow-up data were collected and analyzed. To investigate the factors influencing the benign or malignant nature of SPN, we employed logistic regression. Additionally, we utilized Kaplan-Meier curves to depict and analyze the overall prognosis.
A total of 195 patients were included, 163 of whom were female and the average age of all patients was 31.7 years old. Among 195 patients, 101 patients (51.8%) had no obvious clinical symptoms and their pancreatic lesions were detected during routine examination. The primary symptom was abdominal pain and distension in 64 cases (32.8%). The maximum diameter of SPN tumors ranged from 1-17 cm (mean 6.19 cm). Forty-eight postoperative complications developed in 43 (22.1%) patients. After a median follow-up duration of 44.5 months, the overall 5-year survival rate was 98.8% and the recurrence rate was 1.5%. Furthermore, we observed a statistically significant difference in the completeness of the tumor capsule between benign and malignant SPN.
SPN is associated with a favorable long-term survival after surgery in our large sample size cohort. For malignant SPN, tumor capsule incompleteness is an independent risk factor.
胰腺实性假乳头状瘤（SPN）是一种罕见的胰腺外分泌肿瘤。本研究旨在总结SPN的临床特征，并分析SPN恶变的危险因素。
回顾性分析2013年5月至2022年9月间经病理确诊为SPN的患者。收集并分析患者的人口统计学数据、临床和病理特征以及随访数据。为研究影响SPN良恶性的因素，我们采用了逻辑回归分析。此外，我们利用Kaplan-Meier曲线描述并分析总体预后情况。
共纳入195例患者，其中女性163例，所有患者的平均年龄为31.7岁。195例患者中，101例（51.8%）无明显临床症状，其胰腺病变在常规检查中被发现。主要症状为腹痛腹胀64例（32.8%）。SPN肿瘤最大直径为1 - 17 cm（平均6.19 cm）。43例（22.1%）患者术后发生48例并发症。中位随访时间44.5个月后，总体5年生存率为98.8%，复发率为1.5%。此外，我们观察到良性和恶性SPN在肿瘤包膜完整性方面存在统计学显著差异。
在我们的大样本队列中，SPN术后长期生存良好。对于恶性SPN，肿瘤包膜不完整是一个独立的危险因素。
