脚桥被盖核在睡眠-觉醒状态中的调节。
The regulation of the pedunculopontine tegmental nucleus in sleep-wake states.
作者信息
Luo Yiting, Li Ying, Yuan Jie
机构信息
Department of Anesthesiology, The Affiliated Hospital of Zunyi Medical University, No.149 Dalian Road, Huichuan District, Zunyi, 563000 Guizhou China.
Department of Pain Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000 Guizhou China.
出版信息
Sleep Biol Rhythms. 2023 Sep 26;22(1):5-11. doi: 10.1007/s41105-023-00489-7. eCollection 2024 Jan.
The pedunculopontine tegmental nucleus (PPTg) plays a vital role in sleep/wake states. There are three main kinds of heterogeneous neurons involved: cholinergic, glutamatergic, and gamma-aminobutyric acidergic (GABAergic) neurons. However, the precise roles of cholinergic, glutamatergic and GABAergic PPTg cell groups in regulating sleep-wake are unknown. Recent work suggests that the cholinergic, glutamatergic, and GABAergic neurons of the PPTg may activate the main arousal-promoting nucleus, thus exerting their wakefulness effects. We review the related projection pathways and functions of various neurons of the PPTg, especially the mechanisms of the PPTg in sleep-wake, thus providing new perspectives for research of sleep-wake mechanisms.
脚桥被盖核在睡眠/觉醒状态中起着至关重要的作用。其中涉及三种主要的异质性神经元：胆碱能神经元、谷氨酸能神经元和γ-氨基丁酸能（GABA能）神经元。然而，胆碱能、谷氨酸能和GABA能的脚桥被盖核细胞群在调节睡眠-觉醒中的具体作用尚不清楚。最近的研究表明，脚桥被盖核的胆碱能、谷氨酸能和GABA能神经元可能激活主要的促觉醒核团，从而发挥其促觉醒作用。我们综述了脚桥被盖核各种神经元的相关投射通路和功能，尤其是脚桥被盖核在睡眠-觉醒中的机制，从而为睡眠-觉醒机制的研究提供新的视角。
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