Correa Luana Barbosa, Gomes-da-Silva Natália Cristina, Dos Santos Clenilton Costa, Rebelo Alencar Luciana Magalhães, Graças Muller de Oliveira Henriques Maria das, Bhattarai Prapanna, Zhu Lin, Noronha Souza Pedro Filho, Rosas Elaine Cruz, Santos-Oliveira Ralph
Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy & Synthesis of New Radiopharmaceuticals, Rio de Janeiro RJ, 21941906, Brazil.
Laboratory of Applied Pharmacology, Farmanguinhos, Oswaldo Cruz Foundation, Rio de Janeiro, 21040-360, Brazil.
Ther Deliv. 2024 Mar 12;15(5):325-38. doi: 10.4155/tde-2023-0088.
This study explores chia oil, rich in ω-3 fatty acids and nutraceutical components, as a potential remedy for diseases, especially those linked to inflammation and cancer. A chia oil-based nanoemulsion, developed through single emulsification, underwent comprehensive analysis using various techniques. and assays, including macrophage polarization, nitrite and cytokine production, cellular uptake and biodistribution, were conducted to assess the anti-inflammatory efficacy. Results reveal that the chia nanoemulsion significantly inhibits inflammation, outperforming pure oil with twice the efficacy. Enhanced uptake by macrophage-like cells and substantial accumulation in key organs indicate its potential as an economical and effective anti-inflammatory nanodrug, addressing global economic and health impacts of inflammation-related diseases.
本研究探索富含ω-3脂肪酸和营养成分的奇亚籽油作为疾病的潜在治疗方法，尤其是那些与炎症和癌症相关的疾病。通过单乳化法制备的基于奇亚籽油的纳米乳剂，使用各种技术进行了全面分析。并进行了包括巨噬细胞极化、亚硝酸盐和细胞因子产生、细胞摄取和生物分布等测定，以评估其抗炎效果。结果表明，奇亚纳米乳剂能显著抑制炎症，其效果优于纯油，功效是纯油的两倍。巨噬细胞样细胞对其摄取增强以及在关键器官中的大量积累表明，它有潜力成为一种经济有效的抗炎纳米药物，可应对与炎症相关疾病对全球经济和健康的影响。
