用于生物医学应用的放射性标记纳米材料：纳米技术时代的放射性药物学。
Radiolabeled nanomaterials for biomedical applications: radiopharmacy in the era of nanotechnology.
作者信息
Pijeira Martha Sahylí Ortega, Viltres Herlys, Kozempel Jan, Sakmár Michal, Vlk Martin, İlem-Özdemir Derya, Ekinci Meliha, Srinivasan Seshasai, Rajabzadeh Amin Reza, Ricci-Junior Eduardo, Alencar Luciana Magalhães Rebelo, Al Qahtani Mohammed, Santos-Oliveira Ralph
机构信息
Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Nuclear Engineering Institute, Brazilian Nuclear Energy Commission, Rua Helio de Almeida, 75, Ilha Do Fundão, Rio de Janeiro, RJ, 21941906, Brazil.
School of Engineering Practice and Technology, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.
出版信息
EJNMMI Radiopharm Chem. 2022 Apr 25;7(1):8. doi: 10.1186/s41181-022-00161-4.
BACKGROUND
Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. Nanomedicine, a term for the application of nanotechnology in medical and health fields, uses nanoparticles for several applications such as imaging, diagnostic, targeted cancer therapy, drug and gene delivery, tissue engineering, and theranostics.
RESULTS
Here, we overview the current state-of-the-art of radiolabeled nanoparticles for molecular imaging and radionuclide therapy. Nanostructured radiopharmaceuticals of technetium-99m, copper-64, lutetium-177, and radium-223 are discussed within the scope of this review article.
CONCLUSION
Nanoradiopharmaceuticals may lead to better development of theranostics inspired by ingenious delivery and imaging systems. Cancer nano-theranostics have the potential to lead the way to more specific and individualized cancer treatment.
背景
纳米技术的最新进展为癌症检测、预防和治疗带来了新希望。纳米医学是纳米技术在医学和健康领域应用的术语，使用纳米颗粒进行多种应用，如成像、诊断、靶向癌症治疗、药物和基因递送、组织工程以及诊疗一体化。
结果
在此，我们概述了用于分子成像和放射性核素治疗的放射性标记纳米颗粒的当前技术水平。本综述文章范围内讨论了锝-99m、铜-64、镥-177和镭-223的纳米结构放射性药物。
结论
纳米放射性药物可能会因巧妙的递送和成像系统而推动诊疗一体化的更好发展。癌症纳米诊疗一体化有潜力引领更具特异性和个体化的癌症治疗方向。
Zotero 插件