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解锁肿瘤标志物的潜力:临床治疗诊断学的进展。

Unlocking the potential of oncology biomarkers: advancements in clinical theranostics.

机构信息

Joint Laboratory of Artificial Intelligence for Critical Care Medicine, Department of Critical Care Medicine and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, 34753 Sichuan University , Chengdu, P.R. China.

iGlobal Research and Publishing Foundation, New Delhi, India.

出版信息

Drug Metab Pers Ther. 2024 Mar 12;39(1):5-20. doi: 10.1515/dmpt-2023-0056. eCollection 2024 Mar 1.

Abstract

INTRODUCTION

Cancer biomarkers have revolutionized the field of oncology by providing valuable insights into tumor changes and aiding in screening, diagnosis, prognosis, treatment prediction, and risk assessment. The emergence of "omic" technologies has enabled biomarkers to become reliable and accurate predictors of outcomes during cancer treatment.

CONTENT

In this review, we highlight the clinical utility of biomarkers in cancer identification and motivate researchers to establish a personalized/precision approach in oncology. By extending a multidisciplinary technology-based approach, biomarkers offer an alternative to traditional techniques, fulfilling the goal of cancer therapeutics to find a needle in a haystack.

SUMMARY AND OUTLOOK

We target different forms of cancer to establish a dynamic role of biomarkers in understanding the spectrum of malignancies and their biochemical and molecular characterization, emphasizing their prospective contribution to cancer screening. Biomarkers offer a promising avenue for the early detection of human cancers and the exploration of novel technologies to predict disease severity, facilitating maximum survival and minimum mortality rates. This review provides a comprehensive overview of the potential of biomarkers in oncology and highlights their prospects in advancing cancer diagnosis and treatment.

摘要

简介

癌症生物标志物通过提供有关肿瘤变化的有价值的见解,并有助于筛查、诊断、预后、治疗预测和风险评估,彻底改变了肿瘤学领域。“组学”技术的出现使生物标志物成为癌症治疗过程中可靠和准确的结果预测指标。

内容

在这篇综述中,我们强调了生物标志物在癌症识别中的临床应用,并激励研究人员在肿瘤学中建立个性化/精准治疗方法。通过扩展基于多学科技术的方法,生物标志物为传统技术提供了替代方案,实现了癌症治疗学找到大海捞针的目标。

总结和展望

我们针对不同形式的癌症,建立了生物标志物在理解恶性肿瘤及其生化和分子特征方面的动态作用,强调了它们在癌症筛查方面的预期贡献。生物标志物为人类癌症的早期检测和探索预测疾病严重程度的新技术提供了有前途的途径,有助于最大限度地提高生存率和降低死亡率。本综述全面概述了生物标志物在肿瘤学中的潜力,并强调了它们在推进癌症诊断和治疗方面的前景。

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