Department of Ophthalmology, Soonchunhyang University College of Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea.
Institute of Health Services Research, Yonsei University, Seoul, Republic of Korea.
J Gerontol A Biol Sci Med Sci. 2024 May 1;79(5). doi: 10.1093/gerona/glae081.
Although the role of the vascular component in the pathophysiology of Parkinson's disease is widely accepted and retinal vascular abnormalities are commonly observed in Parkinson's disease patients, evidence connecting retinal vascular disorders with the risk of developing Parkinson's disease is limited. We aimed to investigate the association between retinal vascular occlusion (RVO) and the risk of developing Parkinson's disease in people over 60 years using a nationwide cohort.
From the 14-year South Korean National Health Insurance Service-Senior cohort, 11 210 incident RVO patients and 11 210 propensity scores, risk-matched controls were included. The incidence of Parkinson's disease was estimated with a Poisson regression. A Cox proportional hazards regression model was used to investigate the associations between RVO and the risk of Parkinson's disease.
The incidence of Parkinson's disease was 664.4 cases per 100 000 person-years (95% confidence interval [CI], 599.7-736.0) in the RVO cohort. Individuals with RVO had an increased incidence of Parkinson's disease (hazard ratio [HR], 1.28; 95% CI: 1.10-1.49). Increased PD risk was predominantly observed in retinal artery occlusion patients (HR, 1.53; 95% CI: 1.11-2.12), male patients (HR, 1.67; 95% CI: 1.29-2.17), and 5 years after diagnosis (HR, 1.46; 95% CI: 1.10-1.93).
Our findings suggest that a common pathophysiological pathway, such as vasculature changes, may exist between RVO and Parkinson's disease. RVO may be one of the risk factors associated with future development of Parkinson's disease. The nature of this association warrants further investigation.
尽管血管成分在帕金森病的病理生理学中的作用已被广泛接受，并且在帕金森病患者中经常观察到视网膜血管异常，但将视网膜血管疾病与帕金森病发病风险联系起来的证据有限。我们旨在使用全国性队列研究调查 60 岁以上人群中视网膜血管闭塞（RVO）与帕金森病发病风险之间的关系。
从为期 14 年的韩国国家健康保险服务-老年人队列中，纳入了 11210 例新发 RVO 患者和 11210 例倾向评分、风险匹配的对照组。使用泊松回归估计帕金森病的发病率。使用 Cox 比例风险回归模型研究 RVO 与帕金森病风险之间的关系。
RVO 队列中帕金森病的发病率为每 100000 人年 664.4 例（95%置信区间[CI]：599.7-736.0）。患有 RVO 的个体患帕金森病的发病率增加（风险比[HR]，1.28；95%CI：1.10-1.49）。主要观察到 RVO 患者（HR，1.53；95%CI：1.11-2.12）、男性患者（HR，1.67；95%CI：1.29-2.17）和诊断后 5 年（HR，1.46；95%CI：1.10-1.93）帕金森病风险增加。
我们的研究结果表明，RVO 和帕金森病之间可能存在共同的病理生理途径，如血管变化。RVO 可能是与未来帕金森病发展相关的危险因素之一。这种关联的性质需要进一步研究。
