Kubena L F, Harvey R B, Fletcher O J, Phillips T D, Mollenhauer H H, Witzel D A, Heidelbaugh N D
Poult Sci. 1985 Apr;64(4):620-8. doi: 10.3382/ps.0640620.
The effects of ochratoxin A (OA) and vanadium (V), singly and in combination, were determined in male Leghorn chicks from 1 to 28 days of age. The chicks were fed a control diet containing the following additives: A) none; B) 2.5 mg OA/kg; C) 50 mg V/kg; D) 2.5 mg OA plus 50 mg V/kg. These data show that body weight gains were significantly reduced by OA and V singly, and a toxicity-enhancing synergism exists between OA and V, which caused a further reduction in performance. The OA-V combination caused a significant increase in the relative weights of the liver, kidney, gizzard, and proventriculus and a significant decrease in the relative weights of the bursa of Fabricius. This decrease in bursal weight was due to atrophy of lymphoid follicles as indicated by the increase in the histologic lesion score. Uric acid in serum was increased, and albumin, calcium, and phosphorus were decreased in the OA-V combination group. There were also small but significant changes in the hematological parameters measured. Distribution of OA to the liver and kidney was not altered, nor was the distribution of V to the liver, kidney, or muscle tissue. Histologic lesions in kidneys were mild but were more prevalent in chicks in the OA-V combination group.
研究了单独及联合使用赭曲霉毒素A（OA）和钒（V）对1至28日龄雄性来航鸡的影响。给雏鸡饲喂含有以下添加剂的对照日粮：A）无添加剂；B）2.5毫克OA/千克；C）50毫克V/千克；D）2.5毫克OA加50毫克V/千克。这些数据表明，单独使用OA和V均显著降低了体重增加，且OA和V之间存在毒性增强的协同作用，这导致生产性能进一步下降。OA-V组合使肝脏、肾脏、肌胃和腺胃的相对重量显著增加，法氏囊的相对重量显著降低。法氏囊重量的降低是由于淋巴滤泡萎缩，组织学病变评分增加表明了这一点。OA-V组合组血清尿酸增加，白蛋白、钙和磷减少。所测量的血液学参数也有微小但显著的变化。OA在肝脏和肾脏中的分布没有改变，V在肝脏、肾脏或肌肉组织中的分布也没有改变。肾脏的组织学病变较轻，但在OA-V组合组的雏鸡中更普遍。
