Schneeweiss U, Fabricius E M, Schmidt W
Zentralbl Bakteriol Orig A. 1979 Jun;243(4):528-41.
After injection of known numbers of viable tumour cells admixed with tetanus spores into the subcutaneous tissue between the shoulder blades the sigmoidal tetanus lethality curves of mice can be quantitatively analysed following the underlying growth of tetanus clostridia and tumour cells. We suggest that the "driving force" for exponential clostridial growth and toxin synthesis are oxygen-consuming clones of tumour cells. Our experimental data are in good accordance with a stochastic mathematical model which allows for computing the cloning probability of one single spore on the basis of a 1-mitosis-1-clostridium division-principle.
将已知数量的活肿瘤细胞与破伤风芽孢混合后注射到小鼠肩胛骨之间的皮下组织中，随着破伤风梭菌和肿瘤细胞的生长，可以对小鼠的S形破伤风致死率曲线进行定量分析。我们认为，肿瘤细胞的耗氧克隆是梭菌指数生长和毒素合成的“驱动力”。我们的实验数据与一个随机数学模型高度吻合，该模型允许基于1次有丝分裂-1个梭菌分裂原则计算单个芽孢的克隆概率。
