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肝硬化患者的手术风险分层。

Surgical risk stratification in patients with cirrhosis.

机构信息

Division of Gastroenterology, Department of Internal Medicine, University Hospital Center Zagreb, Kispaticeva 12, Zagreb, 10000, Croatia.

Division of Gastroenterology and Hepatology, University of Pennsylvania, 2 Dulles, 3400 Spruce Street, HUP, Philadelphia, PA, 19104, USA.

出版信息

Hepatol Int. 2024 Jun;18(3):876-891. doi: 10.1007/s12072-024-10644-y. Epub 2024 Mar 12.

Abstract

Individuals with cirrhosis experience higher morbidity and mortality rates than the general population, irrespective of the type or scope of surgery. This increased risk is attributed to adverse effects of liver disease, encompassing coagulation dysfunction, altered metabolism of anesthesia and sedatives, immunologic dysfunction, hemorrhage related to varices, malnutrition and frailty, impaired wound healing, as well as diminished portal blood flow, overall hepatic circulation, and hepatic oxygen supply during surgical procedures. Therefore, a frequent clinical dilemma is whether surgical interventions should be pursued in patients with cirrhosis. Several risk scores are widely used to aid in the decision-making process, each with specific advantages and limitations. This review aims to discuss the preoperative risk factors in patients with cirrhosis, describe and compare surgical risk assessment models used in everyday practice, provide insights into the surgical risk according to the type of surgery and present recommendations for optimizing those with cirrhosis for surgical procedures. As the primary focus is on currently available risk models, the review describes the predictive value of each model, highlighting its specific advantages and limitations. Furthermore, for models that do not account for the type of surgical procedure to be performed, the review suggests incorporating both patient-related and surgery-related risks into the decision-making process. Finally, we provide an algorithm for the preoperative assessment of patients with cirrhosis before elective surgery as well as guidance perioperative management.

摘要

个体患有肝硬化时,其发病率和死亡率高于普通人群,无论手术类型或范围如何。这种风险增加归因于肝脏疾病的不良影响,包括凝血功能障碍、麻醉和镇静剂代谢改变、免疫功能障碍、与静脉曲张相关的出血、营养不良和虚弱、伤口愈合受损,以及手术过程中门静脉血流量、总体肝循环和肝氧供应减少。因此,临床上经常面临的难题是是否应该对肝硬化患者进行手术干预。目前广泛使用了几种风险评分来辅助决策过程,每种评分都有其特定的优势和局限性。本综述旨在讨论肝硬化患者的术前危险因素,描述和比较日常实践中使用的手术风险评估模型,根据手术类型深入了解手术风险,并为肝硬化患者提出优化手术流程的建议。由于主要重点是目前可用的风险模型,因此该综述描述了每个模型的预测价值,突出了其特定的优势和局限性。此外,对于未考虑要进行的手术类型的模型,综述建议将患者相关和手术相关风险纳入决策过程。最后,我们提供了一个用于择期手术前肝硬化患者术前评估的算法,并提供了围手术期管理的指导。

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