Fjalland B
Psychopharmacology (Berl). 1979 May 25;63(2):113-7. doi: 10.1007/BF00429687.
5-Hydroxytryptophan (5-HTP) and p-methoxyamphetamine (p-MA) induce dose-dependent, lethal hyperthermia when applied intravenously to monoamine oxidase inhibitor (MAOI) pretreated rabbits. The time course of hyperthermia and the doses required to induce hyperthermia varies between the two substances. Results with alpha-MT and PCPA suggest that 5-HTP hyperthermia depends on 5-HT formation, release of endogenous 5-HT, and the presence of catecholamines, whereas p-MA-induced hyperthermia most likely is a result of indirect 5-HT release. Some neuroleptics (piflutixol, spiroperidol and methiotepine) are extremely potent inhibitors of the induced hyperthermia, Also the 5-HT receptor blocking agent methergoline antagonizes hyperthermia induced by the two substances in rather low doses. On the other hand cis (Z)-flupenthixol is a very weak antagonist of 5-HTP but a more potent inhibitor of p-MA hyperthermia. It is concluded that both 5-HT and catecholamine (dopamine) receptor blockade is required to antagonize 5-HTP hyperthermia and that antagonism of p-MA induced hyperthermia is primarily a result of influence on the 5-HT system.
当对用单胺氧化酶抑制剂（MAOI）预处理过的兔子静脉注射5-羟色氨酸（5-HTP）和对甲氧基苯丙胺（p-MA）时，它们会引起剂量依赖性的致死性体温过高。两种物质引起体温过高的时间过程以及诱导体温过高所需的剂量各不相同。用α-甲基酪氨酸（alpha-MT）和对氯苯丙氨酸（PCPA）进行的实验结果表明，5-HTP引起的体温过高取决于5-羟色胺（5-HT）的形成、内源性5-HT的释放以及儿茶酚胺的存在，而p-MA诱导的体温过高很可能是间接释放5-HT的结果。一些抗精神病药物（匹氟噻吨、螺哌利多和甲硫替平）是诱导体温过高的极其有效的抑制剂。5-HT受体阻断剂麦角新碱也能以相当低的剂量拮抗这两种物质诱导的体温过高。另一方面，顺式（Z）-氟哌噻吨是5-HTP的非常弱的拮抗剂，但却是p-MA引起的体温过高的更有效的抑制剂。得出的结论是，拮抗5-HTP引起的体温过高需要同时阻断5-HT和儿茶酚胺（多巴胺）受体，而拮抗p-MA诱导的体温过高主要是对5-HT系统产生影响的结果。
