Spugnini Enrico P, Condello Maria, Crispi Stefania, Baldi Alfonso
Biopulse Srl, 00144 Rome, Italy.
Istituto Superiore di Sanità, 00161 Rome, Italy.
Cancers (Basel). 2024 Mar 6;16(5):1067. doi: 10.3390/cancers16051067.
Electroporation (EP) is a broadly accepted procedure that, through the application of electric pulses with appropriate amplitudes and waveforms, promotes the delivery of anticancer molecules in various oncology therapies. EP considerably boosts the absorptivity of targeted cells to anticancer molecules of different natures, thus upgrading their effectiveness. Its use in veterinary oncology has been widely explored, and some applications, such as electrochemotherapy (ECT), are currently approved as first-line treatments for several neoplastic conditions. Other applications include irreversible electroporation and EP-based cancer vaccines. In human oncology, EP is still mostly restricted to therapies for cutaneous tumors and the palliation of cutaneous and visceral metastases of malignant tumors. Fields where veterinary experience could help smooth the clinical transition to humans include intraoperative EP, interventional medicine and cancer vaccines. This article recapitulates the state of the art of EP in veterinary and human oncology, recounting the most relevant results to date.
电穿孔(EP)是一种被广泛接受的程序,通过施加具有适当幅度和波形的电脉冲,在各种肿瘤治疗中促进抗癌分子的递送。电穿孔大大提高了靶细胞对不同性质抗癌分子的吸收率,从而提升了它们的有效性。其在兽医肿瘤学中的应用已得到广泛探索,一些应用,如电化学疗法(ECT),目前已被批准作为几种肿瘤疾病的一线治疗方法。其他应用包括不可逆电穿孔和基于电穿孔的癌症疫苗。在人类肿瘤学中,电穿孔仍主要限于皮肤肿瘤的治疗以及恶性肿瘤皮肤和内脏转移的姑息治疗。兽医经验有助于向人类临床过渡的领域包括术中电穿孔、介入医学和癌症疫苗。本文概述了电穿孔在兽医和人类肿瘤学中的最新进展,列举了迄今为止最相关的结果。