University Center of Excellence on Nephrologic, Rheumatologic and Rare Diseases (ERK-Net, ERN-Reconnect and RITA-ERN Member) with Nephrology and Dialysis Unit and Center of Immuno-Rheumatology and Rare Diseases (CMID), Coordinating Center of the Interregional Network for Rare Diseases of Piedmont and Aosta Valley, ASL Città di Torino and Department of Clinical and Biological Sciences, University of Turin, 10154 Turin, Italy.
Int J Mol Sci. 2024 Mar 1;25(5):2853. doi: 10.3390/ijms25052853.
The lymphatic kidney system plays a crucial role in managing interstitial fluid removal, regulating fluid balance, and tuning immune response. It also assists in the reabsorption of proteins, electrolytes, cytokines, growth factors, and immune cells. Pathological conditions, including tissue damage, excessive interstitial fluid, high blood glucose levels, and inflammation, can initiate lymphangiogenesis-the formation of new lymphatic vessels. This process is associated with various kidney diseases, including polycystic kidney disease, hypertension, ultrafiltration challenges, and complications post-organ transplantation. Although lymphangiogenesis has beneficial effects in removing excess fluid and immune cells, it may also contribute to inflammation and fibrosis within the kidneys. In this review, we aim to discuss the biology of the lymphatic system, from its development and function to its response to disease stimuli, with an emphasis on renal pathophysiology. Furthermore, we explore how innovative treatments targeting the lymphatic system could potentially enhance the management of kidney diseases.
淋巴肾脏系统在管理间质液清除、调节液体平衡和调整免疫反应方面起着至关重要的作用。它还有助于蛋白质、电解质、细胞因子、生长因子和免疫细胞的重吸收。组织损伤、间质液过多、高血糖水平和炎症等病理条件会引发淋巴管生成——新淋巴管的形成。这一过程与多种肾脏疾病有关，包括多囊肾病、高血压、超滤挑战和器官移植后的并发症。尽管淋巴管生成在清除多余液体和免疫细胞方面具有有益作用，但它也可能导致肾脏内的炎症和纤维化。在这篇综述中，我们旨在讨论淋巴系统的生物学特性，从其发育和功能到对疾病刺激的反应，重点是肾脏病理生理学。此外，我们探讨了靶向淋巴系统的创新治疗方法如何有可能增强对肾脏疾病的管理。
