Jiménez Diego J, Javed Aadil, Rubio-Tomás Teresa, Seye-Loum Ndioba, Barceló Carles
Translational Pancreatic Cancer Oncogenesis Group, Health Research Institute of the Balearic Islands (IdISBa), Hospital Universitari Son Espases, 07120 Palma de Mallorca, Spain.
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Int J Mol Sci. 2024 Mar 1;25(5):2860. doi: 10.3390/ijms25052860.
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related death worldwide. It is commonly diagnosed in advanced stages and therapeutic interventions are typically constrained to systemic chemotherapy, which yields only modest clinical outcomes. In this review, we examine recent developments in targeted therapy tailored to address distinct molecular pathway alteration required for PDAC. Our review delineates the principal signaling pathways and molecular mechanisms implicated in the initiation and progression of PDAC. Subsequently, we provide an overview of prevailing guidelines, ongoing investigations, and prospective research trajectories related to targeted therapeutic interventions, drawing insights from randomized clinical trials and other pertinent studies. This review focus on a comprehensive examination of preclinical and clinical data substantiating the efficacy of these therapeutic modalities, emphasizing the potential of combinatorial regimens and novel therapies to enhance the quality of life for individuals afflicted with PDAC. Lastly, the review delves into the contemporary application and ongoing research endeavors concerning targeted therapy for PDAC. This synthesis serves to bridge the molecular elucidation of PDAC with its clinical implications, the evolution of innovative therapeutic strategies, and the changing landscape of treatment approaches.
胰腺导管腺癌（PDAC）是全球癌症相关死亡的主要原因之一。它通常在晚期被诊断出来，治疗干预通常局限于全身化疗，而全身化疗的临床效果有限。在本综述中，我们研究了针对PDAC所需的不同分子途径改变的靶向治疗的最新进展。我们的综述阐述了与PDAC的发生和发展相关的主要信号通路和分子机制。随后，我们从随机临床试验和其他相关研究中汲取见解，概述了与靶向治疗干预相关的现行指南、正在进行的研究以及前瞻性研究轨迹。本综述着重全面审视支持这些治疗方式疗效的临床前和临床数据，强调联合治疗方案和新型疗法改善PDAC患者生活质量的潜力。最后，综述深入探讨了PDAC靶向治疗的当代应用和正在进行的研究工作。这一综合论述旨在将PDAC的分子解析与其临床意义、创新治疗策略的演变以及治疗方法的不断变化联系起来。
