铑催化碳酸乙烯基亚乙酯与亚硝基苯亚胺的串联不对称烯丙基脱羧加成和环化反应
Rhodium-Catalyzed Tandem Asymmetric Allylic Decarboxylative Addition and Cyclization of Vinylethylene Carbonates with -Nosylimines.
作者信息
Wang Xiao-Lin, Jiang Hai-Bin, Zheng Sheng-Cai, Zhao Xiao-Ming
机构信息
School of Chemical Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, China.
出版信息
Molecules. 2024 Feb 26;29(5):1019. doi: 10.3390/molecules29051019.
Abstract
A enantioselective tandem transformation, concerning asymmetric allylic decarboxylative addition and cyclization of -nosylimines with vinylethylene carbonates (VECs), in the presence of [Rh(CH)Cl], chiral sulfoxide--olefin tridentate ligand has been developed. The reaction of VECs with various substituted -nosylimines proceeded smoothly under mild conditions, providing highly functionalized oxazolidine frameworks in good to high yields with good to excellent enantioselectivity.
摘要
已开发出一种对映选择性串联转化反应，该反应涉及在[Rh(CH)Cl]和手性亚砜-烯烃三齿配体存在下，-亚磺酰亚胺与碳酸乙烯亚乙酯（VECs）的不对称烯丙基脱羧加成和环化反应。VECs与各种取代的-亚磺酰亚胺的反应在温和条件下顺利进行，以良好至高产率和良好至优异的对映选择性提供了高度官能化的恶唑烷骨架。
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