State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao 266000, China.
Food Laboratory of Zhongyuan, Luohe 462300, China.
Nutrients. 2024 Feb 28;16(5):680. doi: 10.3390/nu16050680.
Lactic-acid-bacteria-derived bacteriocins are used as food biological preservatives widely. Little information is available on the impact of bacteriocin intake with food on gut microbiota in vivo. In this study, the effects of fermented milk supplemented with nisin (FM-nisin) or plantaricin Q7 (FM-Q7) from Q7 on inflammatory factors and the gut microbiota of mice were investigated. The results showed that FM-nisin or FM-Q7 up-regulated IFN-γ and down-regulated IL-17 and IL-12 in serum significantly. FM-nisin down-regulated TNF-α and IL-10 while FM-Q7 up-regulated them. The results of 16S rRNA gene sequence analysis suggested that the gut microbiome in mice was changed by FM-nisin or FM-Q7. The ratio was reduced significantly in both groups. It was observed that the volume of was significantly reduced whereas those of and were increased. The total number of short-chain fatty acids (SCFAs) in the mouse feces of the FM-nisin group and FM-Q7 group was increased. The content of acetic acid was increased while the butyric acid content was decreased significantly. These findings indicated that FM-nisin or FM-Q7 could stimulate the inflammation response and alter gut microbiota and metabolic components in mice. Further in-depth study is needed to determine the impact of FM-nisin or FM-Q7 on the host's health.
乳酸菌源细菌素被广泛用作食品生物防腐剂。关于食物中摄入细菌素对体内肠道微生物群的影响，信息很少。在这项研究中，研究了添加乳链菌肽（FM-nisin）或植物乳杆菌素 Q7（FM-Q7）的发酵乳对小鼠炎症因子和肠道微生物群的影响。结果表明，FM-nisin 或 FM-Q7 可显著上调血清中 IFN-γ，下调 IL-17 和 IL-12。FM-nisin 下调 TNF-α和 IL-10，而 FM-Q7 则上调它们。16S rRNA 基因序列分析结果表明，FM-nisin 或 FM-Q7 改变了小鼠的肠道微生物群。两组的 比例均显著降低。观察到 的体积明显减少，而 和 的体积增加。FM-nisin 组和 FM-Q7 组小鼠粪便中的短链脂肪酸（SCFA）总量增加。乙酸含量增加，丁酸含量显著降低。这些发现表明，FM-nisin 或 FM-Q7 可刺激炎症反应，并改变小鼠的肠道微生物群和代谢成分。需要进一步深入研究以确定 FM-nisin 或 FM-Q7 对宿主健康的影响。
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