Li Ping, Li Ming, Wu Tao, Song Ying, Li Yan, Huang Xiaochang, Lu Hui, Xu Zhenjiang Zech
State Key Laboratory of Food Science and Technology, Nanchang University, No. 235 Nanjing East Road, Nanchang, 330047, China.
NPJ Sci Food. 2022 Sep 13;6(1):42. doi: 10.1038/s41538-022-00158-y.
Certain antimicrobial preservatives (APs) have been shown to perturb gut microbiota. So far, it is not yet fully known that whether similar effects are observable for a more diverse set of APs. It also remains elusive if biogenic APs are superior to synthetic APs in terms of safety. To help fill these knowledge gaps, the effects of eleven commonly used synthetic and biogenic APs on the gut microbiota and glucose metabolism were evaluated in the wild-type healthy mice. Here, we found that APs induced glucose intolerance and perturbed gut microbiota, irrespective of their origin. In addition, biogenic APs are not always safer than synthetic ones. The biogenic AP nisin unexpectedly induced the most significant effects, which might be partially mediated by glucagon-like peptide 1 related glucoregulatory hormones secretion perturbation.
某些抗菌防腐剂（APs）已被证明会扰乱肠道微生物群。到目前为止，对于更多种类的APs是否能观察到类似的效果还不完全清楚。生物源APs在安全性方面是否优于合成APs也仍然难以捉摸。为了填补这些知识空白，我们在野生型健康小鼠中评估了11种常用的合成和生物源APs对肠道微生物群和葡萄糖代谢的影响。在此，我们发现，无论其来源如何，APs都会诱导葡萄糖不耐受并扰乱肠道微生物群。此外，生物源APs并不总是比合成APs更安全。生物源AP乳酸链球菌素意外地产生了最显著的影响，这可能部分由胰高血糖素样肽1相关的葡萄糖调节激素分泌紊乱介导。
