Omoto Takahiro, Kyozuka Hyo, Murata Tsuyoshi, Fukuda Toma, Isogami Hirotaka, Okoshi Chihiro, Yasuda Shun, Yamaguchi Akiko, Sato Akiko, Ogata Yuka, Nagasaka Yuichi, Hosoya Mitsuaki, Yasumura Seiji, Hashimoto Koichi, Nishigori Hidekazu, Fujimori Keiya
Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima 960-1295, Japan.
Department of Obstetrics and Gynecology, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Nutrients. 2024 Feb 29;16(5):713. doi: 10.3390/nu16050713.
Preterm birth (PTB) is a leading cause of neonatal morbidity and mortality. Therefore, this study aimed to determine whether preconception dietary fiber intake is associated with PTB. This was a prospective cohort Japan Environmental and Children's Study (JECS). The study population comprised 85,116 singleton live-birth pregnancies from the JECS database delivered between 2011 and 2014. The participants were categorized into five groups based on their preconception dietary fiber intake quintiles (Q1 and Q5 were the lowest and highest groups, respectively). Multiple logistic regression analysis was performed to determine the association between preconception dietary fiber intake and PTB. Multiple logistic regression analysis revealed that the risk for PTB before 34 weeks was lower in the Q3, Q4, and Q5 groups than in the Q1 group (Q3: adjusted odds ratio [aOR] 0.78, 95% confidence interval [CI] 0.62-0.997; Q4: aOR 0.74, 95% CI 0.57-0.95; Q5: aOR 0.68, 95% CI 0.50-0.92). However, there was no significant difference between preconception dietary fiber intake and PTB before 37 weeks. In conclusion, higher preconception dietary fiber intake correlated with a reduced the risk for PTB before 34 weeks. Therefore, new recommendations on dietary fiber intake as part of preconception care should be considered.
早产是新生儿发病和死亡的主要原因。因此，本研究旨在确定孕前膳食纤维摄入量是否与早产有关。这是一项前瞻性队列研究——日本环境与儿童研究（JECS）。研究人群包括来自JECS数据库在2011年至2014年间分娩的85116例单胎活产妊娠。参与者根据其孕前膳食纤维摄入量五分位数分为五组（Q1和Q5分别为最低和最高组）。进行多因素逻辑回归分析以确定孕前膳食纤维摄入量与早产之间的关联。多因素逻辑回归分析显示，Q3、Q4和Q5组34周前的早产风险低于Q1组（Q3：调整优势比[aOR]0.78，95%置信区间[CI]0.62 - 0.997；Q4：aOR 0.74，95% CI 0.57 - 0.95；Q5：aOR 0.68，95% CI 0.50 - 0.92）。然而，孕前膳食纤维摄入量与37周前的早产之间没有显著差异。总之，较高的孕前膳食纤维摄入量与34周前早产风险降低相关。因此，应考虑将膳食纤维摄入作为孕前保健一部分的新建议。
