Epigenomics and Computational Biology Lab, Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA.
Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.
Nutrients. 2024 Mar 6;16(5):755. doi: 10.3390/nu16050755.
Folate, also known as vitamin B9, facilitates the transfer of methyl groups among molecules, which is crucial for amino acid metabolism and nucleotide synthesis. Adequate maternal folate supplementation has been widely acknowledged for its pivotal role in promoting cell proliferation and preventing neural tube defects. However, in the post-fortification era, there has been a rising concern regarding an excess maternal intake of folic acid (FA), the synthetic form of folate. In this review, we focused on recent advancements in understanding the influence of excess maternal FA intake on offspring. For human studies, we summarized findings from clinical trials investigating the effects of periconceptional FA intake on neurodevelopment and molecular-level changes in offspring. For studies using mouse models, we compiled the impact of high maternal FA supplementation on gene expression and behavioral changes in offspring. In summary, excessive maternal folate intake could potentially have adverse effects on offspring. Overall, we highlighted concerns regarding elevated maternal folate status in the population, providing a comprehensive perspective on the potential adverse effects of excessive maternal FA supplementation on offspring.
叶酸，也被称为维生素 B9，促进分子间甲基基团的转移，这对于氨基酸代谢和核苷酸合成至关重要。充足的母体叶酸补充已被广泛认为在促进细胞增殖和预防神经管缺陷方面发挥着关键作用。然而，在后强化时代，人们越来越关注母体叶酸（FA）摄入过量的问题，FA 是叶酸的合成形式。在这篇综述中，我们重点关注了最近在理解过量母体 FA 摄入对后代影响方面的进展。对于人类研究，我们总结了临床试验中关于围孕期 FA 摄入对后代神经发育和分子水平变化影响的发现。对于使用小鼠模型的研究，我们汇编了母体高叶酸补充对后代基因表达和行为变化的影响。总的来说，母体叶酸摄入过量可能对后代有不良影响。总之，我们强调了人群中母体叶酸水平升高的担忧，为母体 FA 补充过量对后代的潜在不良影响提供了全面的视角。
