Kainz Michael, Perak Stjepan, Stubauer Gerald, Kopp Sonja, Kauscheder Sebastian, Hemetzberger Julia, Martínez Cendrero Adrián, Díaz Lantada Andrés, Tupe Disha, Major Zoltan, Hanetseder Dominik, Hruschka Veronika, Wolbank Susanne, Marolt Presen Darja, Mühlberger Michael, Guillén Elena
Functional Surfaces and Nanostructures, Profactor GmbH, 4407 Steyr-Gleink, Austria.
Department of Mechanical Engineering, Universidad Politécnica de Madrid, 28006 Madrid, Spain.
Polymers (Basel). 2024 Feb 28;16(5):655. doi: 10.3390/polym16050655.
Additive and lithographic manufacturing technologies using photopolymerisation provide a powerful tool for fabricating multiscale structures, which is especially interesting for biomimetic scaffolds and biointerfaces. However, most resins are tailored to one particular fabrication technology, showing drawbacks for versatile use. Hence, we used a resin based on thiol-ene chemistry, leveraging its numerous advantages such as low oxygen inhibition, minimal shrinkage and high monomer conversion. The resin is tailored to applications in additive and lithographic technologies for future biofabrication where fast curing kinetics in the presence of oxygen are required, namely 3D inkjet printing, digital light processing and nanoimprint lithography. These technologies enable us to fabricate scaffolds over a span of six orders of magnitude with a maximum of 10 mm and a minimum of 150 nm in height, including bioinspired porous structures with controlled architecture, hole-patterned plates and micro/submicro patterned surfaces. Such versatile properties, combined with noncytotoxicity, degradability and the commercial availability of all the components render the resin as a prototyping material for tissue engineers.
使用光聚合的增材制造和光刻制造技术为制造多尺度结构提供了一个强大的工具，这对于仿生支架和生物界面尤其有意义。然而，大多数树脂是针对一种特定的制造技术定制的，在通用使用方面存在缺点。因此，我们使用了一种基于硫醇-烯化学的树脂，利用其众多优点，如低氧抑制、最小收缩率和高单体转化率。该树脂适用于未来生物制造的增材制造和光刻技术应用，这些应用需要在有氧情况下具有快速固化动力学，即三维喷墨打印、数字光处理和纳米压印光刻。这些技术使我们能够制造高度跨度达六个数量级、最大为10毫米、最小为150纳米的支架，包括具有可控结构的仿生多孔结构、孔图案化板和微/亚微图案化表面。这些通用特性，再加上无细胞毒性、可降解性以及所有成分的商业可得性，使该树脂成为组织工程师的原型材料。
