Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Eur J Med Res. 2024 Mar 12;29(1):163. doi: 10.1186/s40001-024-01757-z.
Enterocystoplasty is the most commonly used treatment for bladder reconstruction. However, it has some major complications. In this study, we systematically reviewed the alternative techniques for enterocystoplasty using different scaffolds. A comprehensive search was conducted in PubMed, Embase, and Cochrane Library, and a total of 10 studies were included in this study. Five different scaffolds were evaluated, including small intestinal submucosa (SIS), biodegradable scaffolds seeded with autologous bladder muscle and urothelial cells, dura mater, human cadaveric bladder acellular matrix graft, and bovine pericardium. The overall results revealed that bladder reconstruction using regenerative medicine is an excellent alternative method to enterocystoplasty regarding the improvement of bladder capacity, bladder compliance, and maximum detrusor pressure; however, more large-scale studies are required.
肠膀胱扩大术是最常用于膀胱重建的治疗方法。然而，它有一些主要的并发症。在这项研究中，我们系统地回顾了使用不同支架的肠膀胱扩大术的替代技术。在 PubMed、Embase 和 Cochrane Library 中进行了全面检索，共有 10 项研究纳入本研究。评估了五种不同的支架，包括小肠黏膜下层（SIS）、自体膀胱肌肉和尿路上皮细胞种植的生物可降解支架、硬脑膜、人尸体膀胱去细胞基质移植物和牛心包。总体结果表明，使用再生医学进行膀胱重建在改善膀胱容量、顺应性和最大逼尿肌压力方面是肠膀胱扩大术的一种极好的替代方法；然而，还需要更多的大规模研究。
