• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

脑卒中血管内再灌注无效患者的长期预后。

Long term for patients with futile endovascular reperfusion after stroke.

机构信息

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Department of Neurology, Beijing ShiJiTan Hospital, Capital Medical University, Beijing, China.

出版信息

CNS Neurosci Ther. 2024 Mar;30(3):e14588. doi: 10.1111/cns.14588.

DOI:10.1111/cns.14588
PMID:38475869
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10933383/
Abstract

AIMS

With the progress of thrombectomy technology, the vascular recanalization rate of patients with stroke has been continuously improved, but the proportion of futile recanalization (FR) is still quite a few. The long-term prognosis and survival of patients with FR and its influencing factors remain unclear.

METHODS

Consecutive patients who received endovascular treatment (EVT) for ischemic stroke were enrolled between 2013 and 2021 from a single-center prospectively registry study. We evaluated the long-term outcome of these patients by Kaplan-Meier survival analysis, and the multivariable logistic regression curve was performed to analyze influencing factors.

RESULTS

Among 458 patients with FR, 56.4% of patients survived at 1 year, and 50.4% at 2 years. In the multivariate regression analysis, age, premorbid modified Rankin Scale (mRS), National Institutes of Health Stroke Scale (NIHSS), posterior circulation infarct, general anesthesia, symptomatic intracerebral hemorrhage (sICH), and decompressive craniectomy were found to be related to unfavorable outcomes in long-term. Age, premorbid mRS, NIHSS, general anesthesia, and sICH were predictors of long-term mortality.

CONCLUSIONS

Futile recanalization accounts for a large proportion of stroke patients after thrombectomy. This study on the long-term prognosis of such patients is beneficial to the formulation of treatment plans and the prediction of therapeutic effects.

摘要

目的

随着取栓技术的进步,卒中患者的血管再通率不断提高,但无效再通(FR)的比例仍然相当高。FR 患者的长期预后和生存及其影响因素仍不清楚。

方法

本研究纳入了 2013 年至 2021 年期间在单中心前瞻性登记研究中接受血管内治疗(EVT)的缺血性卒中连续患者。我们通过 Kaplan-Meier 生存分析评估这些患者的长期预后,并进行多变量逻辑回归曲线分析影响因素。

结果

在 458 例 FR 患者中,56.4%的患者在 1 年内存活,50.4%的患者在 2 年内存活。多变量回归分析发现,年龄、发病前改良 Rankin 量表(mRS)、美国国立卫生研究院卒中量表(NIHSS)、后循环梗死、全身麻醉、症状性颅内出血(sICH)和去骨瓣减压术与长期不良结局相关。年龄、发病前 mRS、NIHSS、全身麻醉和 sICH 是长期死亡率的预测因素。

结论

取栓后 FR 占卒中患者的很大比例。这项对这类患者长期预后的研究有助于制定治疗计划和预测治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19d6/10933383/8ef688f6e937/CNS-30-e14588-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19d6/10933383/8ef688f6e937/CNS-30-e14588-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19d6/10933383/8ef688f6e937/CNS-30-e14588-g001.jpg

相似文献

1
Long term for patients with futile endovascular reperfusion after stroke.脑卒中血管内再灌注无效患者的长期预后。
CNS Neurosci Ther. 2024 Mar;30(3):e14588. doi: 10.1111/cns.14588.
2
[Influencing factors of futile recanalization after endovascular therapy in acute ischemic stroke patients with large vessel occlusions].[急性大血管闭塞性缺血性卒中患者血管内治疗后再通失败的影响因素]
Zhonghua Yi Xue Za Zhi. 2023 Aug 8;103(29):2218-2224. doi: 10.3760/cma.j.cn112137-20230218-00231.
3
Predictors of Futile Recanalization After Endovascular Treatment in Patients with Acute Ischemic Stroke in a Multicenter Registry Study.多中心注册研究中急性缺血性脑卒中血管内治疗后无效再通的预测因素。
J Stroke Cerebrovasc Dis. 2020 Oct;29(10):105067. doi: 10.1016/j.jstrokecerebrovasdis.2020.105067. Epub 2020 Jul 30.
4
Futile reperfusion of endovascular treatment for acute anterior circulation large vessel occlusion in the ANGEL-ACT registry.ANGEL-ACT 登记研究中急性前循环大血管闭塞血管内治疗的无效再灌注。
J Neurointerv Surg. 2023 Dec 21;15(e3):e363-e368. doi: 10.1136/jnis-2022-019874.
5
Leukoaraiosis is a predictor of futile recanalization in acute ischemic stroke.脑白质疏松症是急性缺血性卒中再通治疗无效的一个预测指标。
J Neurol. 2017 Mar;264(3):448-452. doi: 10.1007/s00415-016-8366-y. Epub 2016 Dec 21.
6
Brain Atrophy and the Risk of Futile Endovascular Reperfusion in Acute Ischemic Stroke.脑萎缩与急性缺血性脑卒中血管内再通治疗无效的风险。
Stroke. 2020 May;51(5):1514-1521. doi: 10.1161/STROKEAHA.119.028511. Epub 2020 Mar 19.
7
Clinical Relevance of Computed Tomography Perfusion-Estimated Infarct Volume in Acute Ischemic Stroke Patients within the 6-h Therapeutic Time Window.6 小时治疗时间窗内急性缺血性脑卒中患者 CT 灌注估计梗死体积的临床相关性。
Cerebrovasc Dis. 2022;51(4):438-446. doi: 10.1159/000519901. Epub 2022 Jan 21.
8
Predictors of Outcome and Hemorrhage in Patients Undergoing Endovascular Therapy with Solitaire Stent for Acute Ischemic Stroke.使用Solitaire支架进行血管内治疗的急性缺血性卒中患者的预后及出血预测因素
PLoS One. 2015 Dec 7;10(12):e0144452. doi: 10.1371/journal.pone.0144452. eCollection 2015.
9
[The association between cortical venous outflow and futile recanalization in patients with acute ischemic stroke due to large vessel occlusion in the anterior circulation].[前循环大血管闭塞所致急性缺血性卒中患者皮质静脉流出与无效再通之间的关联]
Zhonghua Yi Xue Za Zhi. 2023 Aug 8;103(29):2210-2217. doi: 10.3760/cma.j.cn112137-20221230-02729.
10
Futile Recanalization After Endovascular Treatment in Patients With Acute Basilar Artery Occlusion.血管内治疗后急性基底动脉闭塞患者的无效再通。
Neurosurgery. 2023 May 1;92(5):1006-1012. doi: 10.1227/neu.0000000000002313. Epub 2022 Dec 29.

引用本文的文献

1
Post 90-day outcomes of acute ischemic stroke patients following thrombectomy: analysis of real-world data.急性缺血性中风患者血栓切除术后90天的预后:真实世界数据分析
Front Neurol. 2025 Apr 30;16:1543101. doi: 10.3389/fneur.2025.1543101. eCollection 2025.
2
Caloric Restriction Preserves BBB Integrity After Transient Focal Cerebral Ischemia Through Reducing Neutrophil Infiltration.热量限制通过减少中性粒细胞浸润来维持短暂性局灶性脑缺血后的血脑屏障完整性。
CNS Neurosci Ther. 2025 Feb;31(2):e70257. doi: 10.1111/cns.70257.
3
Involvement of Subinsular Territory Stroke as Predictor of Outcome after Successful Endovascular Recanalization of Left Middle Cerebral Artery Occlusion.

本文引用的文献

1
Predictors of functional dependence at one year in acute ischemic stroke with large vessel occlusion.急性大动脉闭塞性缺血性脑卒中患者一年时功能依赖的预测因素。
NeuroRehabilitation. 2023;52(2):187-197. doi: 10.3233/NRE-220269.
2
Impact of smoking on one year functional outcomes after thrombectomy for young stroke patients.吸烟对年轻脑卒中患者取栓术后 1 年功能结局的影响。
J Neurointerv Surg. 2023 Dec 21;15(e3):e343-e348. doi: 10.1136/jnis-2022-019815.
3
Long-term mortality after endovascular thrombectomy for stroke.血管内血栓切除术治疗中风后的长期死亡率。
岛叶下区梗死累及对左侧大脑中动脉闭塞成功血管内再通术后结局的预测价值
Brain Sci. 2024 Aug 30;14(9):885. doi: 10.3390/brainsci14090885.
J Stroke Cerebrovasc Dis. 2022 Dec;31(12):106832. doi: 10.1016/j.jstrokecerebrovasdis.2022.106832. Epub 2022 Oct 17.
4
Five-Year Outcomes After Endovascular Treatment for Large Vessel Occlusion Stroke.大血管闭塞性卒中血管内治疗后的五年结局
Front Neurosci. 2022 Jul 13;16:920731. doi: 10.3389/fnins.2022.920731. eCollection 2022.
5
Predictors of futile recanalization after endovascular treatment in acute ischemic stroke: a meta-analysis.血管内治疗后急性缺血性脑卒中无效再通的预测因素:一项荟萃分析。
J Neurointerv Surg. 2022 Sep;14(9):881-885. doi: 10.1136/neurintsurg-2021-017963. Epub 2021 Sep 20.
6
The Benefit of Endovascular Thrombectomy for Stroke on Functional Outcome Is Sustained at 12 Months.血管内血栓切除术对脑卒中患者功能结局的获益在 12 个月时得以维持。
Cerebrovasc Dis Extra. 2021;11(2):81-86. doi: 10.1159/000517929. Epub 2021 Aug 6.
7
Biomarkers of Unfavorable Outcome in Acute Ischemic Stroke Patients with Successful Recanalization by Endovascular Thrombectomy.血管内血栓切除术成功再通的急性缺血性脑卒中患者不良预后的生物标志物。
Cerebrovasc Dis. 2020;49(6):583-592. doi: 10.1159/000510804. Epub 2020 Oct 26.
8
Impact of leukoaraiosis severity on the association of outcomes of mechanical thrombectomy for acute ischemic stroke: a systematic review and a meta-analysis.脑白质疏松症严重程度对急性缺血性脑卒中机械取栓治疗结局相关性的影响:一项系统评价和荟萃分析。
J Neurol. 2021 Nov;268(11):4108-4116. doi: 10.1007/s00415-020-10167-0. Epub 2020 Aug 28.
9
Long-Term Outcomes of Acute Endovascular Thrombectomy: Tokyo/tama-Registry of Acute Endovascular Thrombectomy (TREAT).急性血管内血栓切除术的长期结果:东京/tama-急性血管内血栓切除术登记处(TREAT)。
World Neurosurg. 2020 Oct;142:e271-e277. doi: 10.1016/j.wneu.2020.06.209. Epub 2020 Jul 1.
10
Predictors of poor clinical outcome despite complete reperfusion in acute ischemic stroke patients.尽管急性缺血性脑卒中患者实现了完全再灌注,但仍存在临床预后不良的预测因素。
J Neurointerv Surg. 2021 Jan;13(1):14-18. doi: 10.1136/neurintsurg-2020-015889. Epub 2020 May 15.