异甜菊醇衍生物的合成、表征及抗增殖作用。
Synthesis, characterization and antiproliferative effects of isosteviol derivatives.
机构信息
School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China.
Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China.
出版信息
J Asian Nat Prod Res. 2024 Jul;26(7):812-823. doi: 10.1080/10286020.2024.2324082. Epub 2024 Mar 13.
Nineteen isosteviol derivatives were designed and synthesized by C-16, C-19 and D-ring modifications of isosteviol. These compounds were screened for their cytotoxic activities against Hela and A549 cells . Among them, the inhibitory effect of compounds and on Hela cells was comparable to that of the positive control gefitinib, and the compounds (IC=7.84 ± 0.84 μM) and (IC=6.89 ± 0.33 μM) exhibited significant cytotoxicity superior to gefitinib (IC=11.02 ± 3.27 μM) against A549 cells.
十九种甜菊醇衍生物通过对甜菊醇的 C-16、C-19 和 D-环修饰设计和合成。这些化合物的细胞毒性活性针对 Hela 和 A549 细胞进行了筛选。其中，化合物 和 对 Hela 细胞的抑制作用可与阳性对照吉非替尼相媲美，而化合物 （IC=7.84±0.84μM）和 （IC=6.89±0.33μM）对 A549 细胞的细胞毒性作用明显优于吉非替尼（IC=11.02±3.27μM）。
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