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具有高度扰动锥形轮廓的锥形光纤表面等离子体共振生物传感器芯片分析

Analysis of Tapered Fibre Optic Surface Plasmon Resonance Bio-Sensor Chip With Highly Perturbed Taper Profiles.

作者信息

Raghuwanshi Sanjeev Kumar

出版信息

IEEE Trans Nanobioscience. 2024 Jul;23(3):439-446. doi: 10.1109/TNB.2024.3376824. Epub 2024 Jul 1.

Abstract

A numerical model based on the Transfer matrix method (TMM) is proposed for the first time to study the gold coated tapered fibre optic surface plasmon resonance (SPR) with eight different types of taper profiles namely linear, exponential-linear, Gaussian, quadratic, sinusoidal, error function type and highly perturbed taper profile so-called chirp type of profile. The performance in terms of sensitivity, full width at half maximum (FWHM), detection accuracy (D.A.), amplitude dip, and half power points are estimated with respect to tapering ratio and choices of taper profile. It is found that sensitivity increased almost linearly with the taper ratio of each taper choice for the account of the reduction of detection accuracy. It has been found that sensitivity is highest for the case of chirp taper profile and lowest for the case of quadratic taper profile at low taper ratio. In this study, the aqueous solution is considered for sensor development which is adulterated by biomolecules species like DNA, blood samples, etc.

摘要

首次提出了一种基于转移矩阵法(TMM)的数值模型,用于研究具有八种不同类型锥度轮廓的镀金锥形光纤表面等离子体共振(SPR),这八种轮廓分别是线性、指数-线性、高斯、二次、正弦、误差函数型以及高度扰动的锥度轮廓,即所谓的啁啾型轮廓。针对锥度比和锥度轮廓的选择,对灵敏度、半高宽(FWHM)、检测精度(D.A.)、幅度凹陷和半功率点等性能进行了评估。结果发现,由于检测精度的降低,灵敏度几乎随着每种锥度选择的锥度比呈线性增加。研究发现,在低锥度比情况下,啁啾锥度轮廓的灵敏度最高,二次锥度轮廓的灵敏度最低。在本研究中,考虑将水溶液用于传感器开发,该水溶液被DNA、血液样本等生物分子种类掺杂。

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