Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland.
J Nucl Cardiol. 2024 May;35:101845. doi: 10.1016/j.nuclcard.2024.101845. Epub 2024 Mar 12.
Atherosclerosis involving vascular beds across the human body remains the leading cause of death worldwide. Coronary and peripheral artery disease, which are almost universally a result of atherosclerotic plaque, can manifest clinically as myocardial infarctions, ischemic stroke, or acute lower-limb ischemia. Beyond imaging myocardial perfusion and blood-flow, nuclear imaging has the potential to depict the activity of the processes that are directly implicated in the atherosclerotic plaque progression and rupture. Out of several tested tracers to date, the literature is most advanced for F-sodium fluoride positron emission tomography. In this review, we present the latest data in the field of atherosclerotic F-sodium fluoride positron emission tomography imaging, discuss the advantages and limitation of the techniques, and highlight the aspects that require further research in the future.
涉及人体血管床的动脉粥样硬化仍然是全球范围内的主要死亡原因。冠状动脉和外周动脉疾病几乎普遍是动脉粥样硬化斑块的结果，临床上可表现为心肌梗死、缺血性中风或急性下肢缺血。除了成像心肌灌注和血流外，核成像还有可能描述直接涉及动脉粥样硬化斑块进展和破裂的过程的活性。在迄今为止测试的几种示踪剂中，文献对 F-氟酸钠正电子发射断层扫描的研究最为先进。在这篇综述中，我们呈现了动脉粥样硬化 F-氟酸钠正电子发射断层扫描成像领域的最新数据，讨论了这些技术的优点和局限性，并强调了未来需要进一步研究的方面。
