Division of Colon and Rectal Surgery, Advocate Lutheran General Hospital, Park Ridge, Illinois, USA.
Division of Colo-Rectal and Peritoneal Surface Oncology, Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, India.
Colorectal Dis. 2024 May;26(5):1059-1060. doi: 10.1111/codi.16945. Epub 2024 Mar 13.
While neoadjuvant chemotherapy has become the standard of care for rectal cancers in most centres, there is much interest in neoadjuvant chemotherapy in colon cancer after the recent publication of the FOxTROT trial. The management of colon cancers seems to be heading down the same path as rectal cancer, where the radicality of surgery is replaced by chemotherapy intensification. The role of demanding procedures such as complete mesocolic excision with central venous ligation in this new paradigm of upfront chemotherapy remains uncertain and uninvestigated.
虽然新辅助化疗已成为大多数中心治疗直肠癌的标准方案，但在最近 FOxTROT 试验发表后，新辅助化疗在结肠癌中也引起了广泛关注。结肠癌的治疗方法似乎正在朝着与直肠癌相同的方向发展，手术的根治性正在被化疗强化所取代。在这种新的化疗方案中，完全结肠系膜切除术联合中央静脉结扎等要求较高的手术的作用仍然不确定，也未得到研究。
