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Stabilin-2 介导的凋亡细胞吞噬作用通过 p38 和 Pbx1 信号诱导白细胞介素-10 的表达。

Stabilin-2 mediated apoptotic cell phagocytosis induces interleukin-10 expression by p38 and Pbx1 signaling.

机构信息

Department of Physiology, Cell and Matrix Research Institute, Kyungpook National University, School of Medicine, Daegu, South Korea.

出版信息

Cell Biochem Biophys. 2024 Jun;82(2):919-925. doi: 10.1007/s12013-024-01243-7. Epub 2024 Mar 13.

DOI:10.1007/s12013-024-01243-7
PMID:38480573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11344723/
Abstract

Apoptotic cell death occurs under normal physiological conditions, such as development, tissue remodeling, and inflammation. Appropriate removal of apoptotic cells by phagocytes and the secretion of anti-inflammatory cytokines such as IL-10 are important mechanisms for maintaining tissue homeostasis. Apoptotic cell phagocytosis is mediated by several phosphatidylserine recognition receptors on non-professional or professional phagocytes, such as neighboring epithelial cells or macrophages. Stabilin-2 is reported as a phosphatidylserine recognition receptor for apoptotic cell phagocytosis, and its downstream signaling pathway for cytoskeletal rearrangement for phagocytosis is well known. However, the mechanisms for stabilin-2-mediated IL-10 production has not yet been reported. In this study, we aimed to investigate stabilin-2 receptor-mediated IL-10 transcription regulation signaling pathway.

摘要

细胞凋亡发生在正常的生理条件下，如发育、组织重塑和炎症。适当的吞噬细胞清除凋亡细胞和分泌抗炎细胞因子如 IL-10 是维持组织内稳态的重要机制。凋亡细胞的吞噬作用是由非专业或专业吞噬细胞（如邻近的上皮细胞或巨噬细胞）上的几种磷脂酰丝氨酸识别受体介导的。Stabilin-2 被报道为凋亡细胞吞噬的磷脂酰丝氨酸识别受体，其下游信号通路用于吞噬作用的细胞骨架重排已广为人知。然而，Stabilin-2 介导的 IL-10 产生的机制尚未报道。在这项研究中，我们旨在研究 Stabilin-2 受体介导的 IL-10 转录调节信号通路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7738/11344723/4ea5e31249b4/12013_2024_1243_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7738/11344723/fc97dfafb554/12013_2024_1243_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7738/11344723/323688308c14/12013_2024_1243_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7738/11344723/721d3daa669a/12013_2024_1243_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7738/11344723/7e61dbca8773/12013_2024_1243_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7738/11344723/4ea5e31249b4/12013_2024_1243_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7738/11344723/fc97dfafb554/12013_2024_1243_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7738/11344723/323688308c14/12013_2024_1243_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7738/11344723/721d3daa669a/12013_2024_1243_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7738/11344723/7e61dbca8773/12013_2024_1243_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7738/11344723/4ea5e31249b4/12013_2024_1243_Fig5_HTML.jpg

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本文引用的文献

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2
Stabilin Receptors: Role as Phosphatidylserine Receptors.稳定素受体：作为磷脂酰丝氨酸受体的作用。
Biomolecules. 2019 Aug 20;9(8):387. doi: 10.3390/biom9080387.
3
ArhGAP12 plays dual roles in Stabilin-2 mediated efferocytosis: Regulates Rac1 basal activity and spatiotemporally turns off the Rac1 to orchestrate phagosome maturation.ArhGAP12 在 Stabilin-2 介导的吞噬作用中发挥双重作用：调节 Rac1 的基础活性，并在时空上关闭 Rac1 以协调吞噬体成熟。
Biochim Biophys Acta Mol Cell Res. 2019 Oct;1866(10):1595-1607. doi: 10.1016/j.bbamcr.2019.07.003. Epub 2019 Jul 10.
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Phagocytosis of apoptotic cells in homeostasis.稳态下凋亡细胞的吞噬作用。
Nat Immunol. 2015 Sep;16(9):907-17. doi: 10.1038/ni.3253.
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Regulation and functions of the IL-10 family of cytokines in inflammation and disease.白细胞介素-10 家族细胞因子在炎症和疾病中的调节和功能。
Annu Rev Immunol. 2011;29:71-109. doi: 10.1146/annurev-immunol-031210-101312.
6
Thymosin beta4 is involved in stabilin-2-mediated apoptotic cell engulfment.胸腺素β4参与稳定素-2介导的凋亡细胞吞噬过程。
FEBS Lett. 2008 Jun 25;582(15):2161-6. doi: 10.1016/j.febslet.2008.03.058. Epub 2008 Jun 2.
7
Requirement of adaptor protein GULP during stabilin-2-mediated cell corpse engulfment.在稳定素-2介导的细胞尸体吞噬过程中衔接蛋白GULP的需求
J Biol Chem. 2008 Apr 18;283(16):10593-600. doi: 10.1074/jbc.M709105200. Epub 2008 Jan 29.
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