Department of Biochemistry, School of Medicine, Dongguk University, Gyeongju 38066, Korea.
Biomedical Research Institute, Korea Institute Science and Technology, Seoul 02792, Korea.
Biomolecules. 2019 Aug 20;9(8):387. doi: 10.3390/biom9080387.
Phosphatidylserine is a membrane phospholipid that is localized to the inner leaflet of the plasma membrane. Phosphatidylserine externalization to the outer leaflet of the plasma membrane is an important signal for various physiological processes, including apoptosis, platelet activation, cell fusion, lymphocyte activation, and regenerative axonal fusion. Stabilin-1 and stabilin-2 are membrane receptors that recognize phosphatidylserine on the cell surface. Here, we discuss the functions of Stabilin-1 and stabilin-2 as phosphatidylserine receptors in apoptotic cell clearance (efferocytosis) and cell fusion, and their ligand-recognition and signaling pathways.
磷脂酰丝氨酸是一种膜磷脂，定位于质膜的内小叶。磷脂酰丝氨酸向质膜外小叶的外排在各种生理过程中是一个重要的信号，包括细胞凋亡、血小板激活、细胞融合、淋巴细胞激活和再生轴突融合。稳定素-1 和稳定素-2 是识别细胞表面磷脂酰丝氨酸的膜受体。在这里，我们讨论了稳定素-1 和稳定素-2 作为凋亡细胞清除（吞噬作用）和细胞融合的磷脂酰丝氨酸受体的功能，以及它们的配体识别和信号通路。
