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一名患有解脲链球菌菌血症的转移性精原细胞瘤患者的中性粒细胞减少性小肠结肠炎

Neutropenic Enterocolitis in a Metastatic Seminoma Patient With Streptococcus gallolyticus Bacteremia.

作者信息

Trika Sona, Munoz Nicholas R, Hussain Mueez, Beshay-Taylor Youstina, Javed Zainub

机构信息

Internal Medicine, Western University of Health Sciences College of Osteopathic Medicine of the Pacific, Pomona, USA.

Internal Medicine, Southwest Healthcare, Temecula, USA.

出版信息

Cureus. 2024 Feb 12;16(2):e54077. doi: 10.7759/cureus.54077. eCollection 2024 Feb.

Abstract

Neutropenic enterocolitis (NEC), also referred to as typhlitis, is a condition associated with a high mortality risk and primarily manifests in immunocompromised patients. It is characterized by ulceration, edema, and hemorrhage affecting the bowel wall. The underlying cause of NEC is postulated as an immunocompromised condition that facilitates bacterial infiltration through compromised bowel mucosa. The high mortality rate is attributable to bowel necrosis, culminating in perforation and sepsis. This report describes a case involving a patient with metastatic seminoma who exhibited seizure-like activity, fever, bacteremia, and NEC. The patient underwent treatment involving broad-spectrum antibiotics and filgrastim. The patient's neutropenia resolved leading to discharge on oral antibiotics. The case reported is unique, as it links NEC to  and seminoma. has not been previously associated with NEC.

摘要

中性粒细胞减少性小肠结肠炎(NEC),也称为盲肠炎,是一种与高死亡风险相关的疾病,主要表现在免疫功能低下的患者中。其特征是肠壁出现溃疡、水肿和出血。NEC的潜在病因被认为是免疫功能低下状态,这使得细菌能够通过受损的肠黏膜浸润。高死亡率归因于肠坏死,最终导致穿孔和败血症。本报告描述了一例涉及转移性精原细胞瘤患者的病例,该患者表现出癫痫样活动、发热、菌血症和NEC。患者接受了广谱抗生素和非格司亭治疗。患者的中性粒细胞减少症得到缓解,随后口服抗生素出院。报告的该病例很独特,因为它将NEC与精原细胞瘤联系起来。精原细胞瘤此前未与NEC相关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f636/10937032/e9106a6be50e/cureus-0016-00000054077-i01.jpg

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