Rodrigues Fabio G, Dasilva Giovanna, Wexner Steven D
Fabio G Rodrigues, Giovanna Dasilva, Steven D Wexner, Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, FL 33331, United States.
World J Gastroenterol. 2017 Jan 7;23(1):42-47. doi: 10.3748/wjg.v23.i1.42.
Neutropenic colitis is a severe condition usually affecting immunocompromised patients. Its exact pathogenesis is not completely understood. The main elements in disease onset appear to be intestinal mucosal injury together with neutropenia and the weakened immune system of the afflicted patients. These initial conditions lead to intestinal edema, engorged vessels, and a disrupted mucosal surface, which becomes more vulnerable to bacterial intramural invasion. Chemotherapeutic agents can cause direct mucosal injury (mucositis) or can predispose to distension and necrosis, thereby altering intestinal motility. This article aims to review current concepts regarding neutropenic colitis' pathogenesis, diagnosis, and management.
中性粒细胞减少性结肠炎是一种严重疾病，通常影响免疫功能低下的患者。其确切发病机制尚未完全明确。疾病发生的主要因素似乎是肠黏膜损伤、中性粒细胞减少以及患病患者免疫系统的减弱。这些初始状况会导致肠水肿、血管充血和黏膜表面破坏，使其更容易受到细菌壁内侵袭。化疗药物可导致直接的黏膜损伤（黏膜炎）或易引发扩张和坏死，从而改变肠道蠕动。本文旨在综述关于中性粒细胞减少性结肠炎发病机制、诊断和管理的当前概念。
