Najary Shaghayegh, Vatankhah Mohammadreza, Khadivi Gita, Salehi Seyyede N, Tabari Mohammad A K, Samieefar Noosha, Behnaz Mohammad
School of Dentistry Shahid Beheshti University of Medical Sciences Tehran Iran.
USERN Office Shahid Beheshti University of Medical Sciences Tehran Iran.
Health Sci Rep. 2024 Mar 13;7(3):e1967. doi: 10.1002/hsr2.1967. eCollection 2024 Mar.
Anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have the potential to alter several biological systems concurrently with remolding the immune system, most of which are related to immunization, while some others are known as adverse effects. This review aims to explore the potential effects of vaccination on the oral microenvironment and classifies them as good, bad, or ugly, with a brief review of facial diseases following coronavirus disease 2019 (COVID-19) vaccination.
This study was a comprehensive review conducted through searching related articles in Medline, Scopus, and Google Scholar databases.
On one side, the "Good" impacts of vaccination on the oro-nasal mucosa are explained as if the mucosal immune responses followed by SARS-CoV-2 vaccines are enough to provide immunity. On the other side, the possible "Bad" and "Ugly" effects of the vaccine, which manifest as orofacial adverse events and autoimmune reactivations, respectively, should be noted. Exacerbation of pre-existing autoimmune conditions such as lichen planus, pemphigus vulgaris, bullous pemphigoid, and Stevens-Johnson syndrome have been reported.
COVID-19 vaccines could affect different biological systems alongside stimulating the immune system, and some of these effects are referred to as adverse effects. Nonetheless, these adverse effects are treatable, and healthcare professionals should not prevent patients from taking the first available vaccination.
抗严重急性呼吸综合征冠状病毒2（SARS-CoV-2）疫苗在重塑免疫系统的同时，有可能同时改变多个生物系统，其中大部分与免疫接种有关，而其他一些则被称为不良反应。本综述旨在探讨疫苗接种对口腔微环境的潜在影响，并将其分类为好、坏或丑，并简要回顾2019冠状病毒病（COVID-19）疫苗接种后的面部疾病。
本研究是一项通过检索Medline、Scopus和谷歌学术数据库中的相关文章进行的综合综述。
一方面，疫苗接种对口腔-鼻腔黏膜的“好”影响被解释为SARS-CoV-2疫苗引发的黏膜免疫反应足以提供免疫力。另一方面，应注意疫苗可能产生的“坏”和“丑”影响，分别表现为口腔面部不良事件和自身免疫反应激活。已有报告称，扁平苔藓、寻常型天疱疮、大疱性类天疱疮和史蒂文斯-约翰逊综合征等既往自身免疫性疾病会加重。
COVID-19疫苗在刺激免疫系统的同时，可能会影响不同的生物系统，其中一些影响被称为不良反应。尽管如此，这些不良反应是可以治疗的，医疗保健专业人员不应阻止患者接种首剂可用疫苗。
