Singh Vivek K, Kumari Neha, Kusumesh Rakhi, Sinha Bibhuti P
Regional Institute of Ophthalmology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.
J Family Med Prim Care. 2024 Jan;13(1):48-53. doi: 10.4103/jfmpc.jfmpc_475_23. Epub 2024 Feb 8.
To determine demographic details, clinical profile, and underlying causes of limbal stem cell deficiency.
Descriptive cross-sectional study.
Patients visiting tertiary referral hospitals between January 2019 and December 2022 who satisfy the criteria for labeling limbal stem cell deficiency (LSCD) were enrolled. Parameters such as age, gender, region, duration, aetiology, and clinical features were noted. Descriptive statistics was applied. The student -test was used.
A total of 731 eyes of 489 patients with LSCD were included in our study, with age ranging from 5 to 85 years (35.0 ± 19.4 years). The most common presenting complaints were a decrease in vision 473 (96.7%), most of them 342 (69.7%) are having history of gradual progression (>3 months), and 245 (50.1%) have bilateral involvement of eyes. Average corneal clarity was found to be grade 1.6 ± 1.2 and average corneal superficial neovascularization was found to be 7.9 ± 4.3 quadrants. Clinically, we found LSCD of about up to 90° in 57 eyes, 90 to 180° in 71 eyes, 215 eyes with 180 to 270°, and the rest of 388 eyes were having more than 270° of LSCD involvement. Out of 489 patients, 142 (29.0%) patients were of chemical injury, 125 (25.6%) patients were of Steven Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), followed by 61 (12.5%) patients of vernal keratoconjunctivitis (VKC).
The majority of patients were young males presented with more than 270° LSCD and vision <2/60. In our study, chemical injury was most common in unilateral LSCD and SJS/TEN in bilateral LSCD.
确定角膜缘干细胞缺乏症的人口统计学细节、临床特征及潜在病因。
描述性横断面研究。
纳入2019年1月至2022年12月期间就诊于三级转诊医院且符合角膜缘干细胞缺乏症（LSCD）诊断标准的患者。记录年龄、性别、地区、病程、病因及临床特征等参数。应用描述性统计方法，采用t检验。
本研究共纳入489例LSCD患者的731只眼，年龄范围为5至85岁（35.0±19.4岁）。最常见的主诉是视力下降473例（96.7%），其中大多数342例（69.7%）有逐渐进展的病史（>3个月），245例（50.1%）双眼受累。平均角膜透明度为1.6±1.2级，平均角膜表面新生血管为7.9±4.3象限。临床上，我们发现57只眼中LSCD约达90°，71只眼中为90至180°，215只眼中为180至270°，其余388只眼中LSCD累及超过270°。在489例患者中，142例（29.0%）为化学伤患者，125例（25.6%）为史蒂文斯 - 约翰逊综合征（SJS）/中毒性表皮坏死松解症（TEN）患者，其次是61例（12.5%）春季角结膜炎（VKC）患者。
大多数患者为年轻男性，表现为超过270°的LSCD且视力<2/60。在我们的研究中，化学伤在单侧LSCD中最常见，SJS/TEN在双侧LSCD中最常见。
