格罗菲他单抗可刺激中枢神经系统肿瘤的免疫细胞浸润，并在继发性中枢神经系统淋巴瘤中诱导临床应答。
Glofitamab stimulates immune cell infiltration of CNS tumors and induces clinical responses in secondary CNS lymphoma.
机构信息
Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA.
Department of Pathology, City of Hope, Duarte, CA.
出版信息
Blood. 2024 Jul 25;144(4):457-461. doi: 10.1182/blood.2024024168.
Abstract
Although CD20×CD3 bispecific antibodies are effective against systemic B-cell lymphomas, their efficacy in central nervous system (CNS) lymphoma is unknown. Here, we report the CD20×CD3 bispecific glofitamab penetrates the blood-brain barrier, stimulates immune-cell infiltration of CNS tumors, and induces clinical responses in patients with secondary CNS.
摘要
虽然 CD20×CD3 双特异性抗体对系统性 B 细胞淋巴瘤有效，但它们在中枢神经系统（CNS）淋巴瘤中的疗效尚不清楚。在这里，我们报告 CD20×CD3 双特异性 glofitamab 可穿透血脑屏障，刺激免疫细胞浸润 CNS 肿瘤，并在继发性 CNS 患者中诱导临床反应。
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